地氯雷他定(TY-DSL)对小鼠致畸性的研究  

Study on teratogenicity of TY-DSL in mice

作　　者：王江[1] 候庆昌[1] 陈绮[1] 张繁[1] 郭启栋[1] 

机构地区：[1]天津市计划生育研究所,天津300191

出　　处：《天津药学》2002年第3期38-40,共3页Tianjin Pharmacy

摘　　要：目的 :地氯雷他定 (TY- DSL )的致畸性研究。方法 :实验分别以 5 6 .9、 2 8.4和 14 .2 m g/ kg剂量 ,给妊娠第 6～ 15日的孕鼠连续定时灌胃 ,在妊娠第 18日时解剖观察孕鼠着床数、活胎、死胎、吸收胎和外观畸形 ,同时测量胎仔体重、胎盘重、身长和尾长。以上数据用 instat软件进行统计学处理。结果 :TY- DSL 在以上 3种剂量下对上述指标均有不同程度的影响 ,尤以中、高剂量组为甚 ,但该药不影响孕鼠的体重和生育力 ,且未见一例外观、内脏和骨骼畸形。结论 :地氯雷他定 (TY- DSL )对小鼠无致畸性。Objective: To study on teratogenicity of TY DSL in mice. Methods: The mice gestating for 6～15 days administrated orally TY DSL in dose range of 14.2～56.9 mg/kg. The pregnant mice were dissected in the pregnant 18th day to observe the fetal numbers of inplantation, living, dead, absorbed fetues ,and surface malformation. Fetal weight, placenta weight, body length, and tail length were measured. Results: The result of experiment showed that the drug from low dose to high dose has different effection, especially in the group of middle and high dose, but this drug does not affect the body weight and fertility of mice, and cause malformation of the fetal surface, bone and internal organs. Conclusion: The present study showed that the TY DSL does not have teratogenicity in the mice.

关 键 词：TY-DSL 致畸性 小鼠 抗过敏药 药物安全性 

分 类 号：R976[医药卫生—药品] R965.3[医药卫生—药学]