人α-干扰素治疗小儿EB病毒感染疗效观察  

Curative effect of human α-interferon on EB virus infection in children

作　　者：牟春笋[1] 王明月[1] 杨力群[1] 张萍[1] 

机构地区：[1]山东省济南铁路中心医院,济南025000

出　　处：《华北煤炭医学院学报》2002年第4期412-413,共2页Journal of North China Coal Medical College

摘　　要：1目的　观察干扰素治疗小儿 EB感染的疗效。 2方法　对 3 8例传染性单核细胞增多症患儿随机分为两组 ,观察组 18例采用人 α-干扰素 10 0万 U肌注每周 2次 ,治疗 2～ 3周 ,同时给予退热等对症处理 ;对照组 2 0例应用病毒唑治疗 ,剂量按 10～ 15 mg/(kg· d)静滴 1/d,连用 10～ 14 d,对症处理同观察组。3结果　观察组在退热时间 (t=4.2 869,P<0 .0 1) ,淋巴结消退时间 (t=5 .42 4,P<0 .0 1) ,异型淋巴细胞消失时间 (t=2 .5 71,P<0 .0 5 )与对照组相比有显著差异 ;促进 EB-VCA-Ig M转阴率高于对照组。 4结论　干扰素是治疗小儿Objective To observe the effect of interferon on EB virus infections.Methods 38 cases of children with infectious mononucleosis have been divided into two groups randomly,18 cases as test group,and 20 cases as contrals.The test group has been treated with human α-interferon,1 million unit im,twice a week,for 2～3 weeks;in the control group,virazole has been given,10～15mg/(kg·d) iv drip qd,for 10～14 days.The same symptomatical treatment has been used in the two groups.Results The test group has significant difference in shortening annealing time(t=4.2869,P<0.01),lymph node vanishing time (t=5.424,P<0.01) and atypical lymphocyte disappearing time (t=2.571,P<0.05),the neqative conversion rate of EB VCA IgM in the two group are 100% and 70% respectively after 3 month,which also has significant difference.Conclusion Interferon is effective for treating EB virus infection.

关 键 词：EB病毒感染 人α-干扰素 传染性单核细胞增多症 小儿 疗效观察 

分 类 号：R725.127[医药卫生—儿科]