地氯雷他定遗传毒性及致畸性实验研究  

Study of genotoxicity and teratogenicity of DSL

作　　者：辛力[1] 王玉梅[1] 陈绮[1] 李伟[1] 王江[1] 

机构地区：[1]天津市计划生育研究所遗传室,天津300191

出　　处：《天津医科大学学报》2002年第2期169-171,174,共4页Journal of Tianjin Medical University

摘　　要：目的 :检测受试物DSL是否具有潜在的遗传毒理及生殖毒理学效应。方法:采用小鼠骨髓嗜多染红细胞(PCE)微核试验、中国仓鼠肺细胞(CHL)染色体畸变试验及致畸试验,对受试物DSL进行了遗传毒性及致畸性检测。结果:小鼠骨髓微核试验和CHL染色体畸变试验均为阴性结果。致畸试验在上述3种剂量下未见明显致畸影响。结论:DSL在本试验范围内未见明显遗传毒性及致畸性效应。但该药可能有弱雌激素活性 。Objective: To study the genotoxicity and reproduction toxicosis about DSL.Mothods: Genotoxicity and teratogenicity of DSL were examined by micronucleus of PCE,chromosome aberration of CHL and teralogenic test.Results: It indicated that DSL did not induce chrosome aberration and increase the frequency of micronuclei, and no significant teratogenicity in three dose groups .Conclusion: DSL have no significantly genotoxicity and teratogenicity effects. Great attention should be paiy when this drug is used for pregnant woman.

关 键 词：DSL 微核试验 染色体畸变试验 致畸试验 

分 类 号：R976[医药卫生—药品]