血清胆红素与冠状动脉病变关系的分析  

Relationship between Serum Bilirubin and Coronary Atherosclerosis

作　　者：夏大胜[1] 党群[1] 刘书坤[1] 张菁[1] 王彦欧[1] 蔡林[1] 周欣[2] 

机构地区：[1]天津市第一中心医院心内科,300192 [2]武警医学院

出　　处：《天津医药》2002年第6期323-325,共3页Tianjin Medical Journal

摘　　要：目的:探讨血清胆红素水平与冠心病的关系。方法:收集经冠状动脉造影确诊的冠心病患者92例、非冠心病患者68例作为研究对象。测定血清总胆红素、直接胆红素、间接胆红素及血脂水平。结果:多支病变患者血清总胆红素、直接胆红素及间接胆红素水平均低于单支病变患者和对照组（P<0.05或P<0.01）,单支病变患者也低于对照组（P<0.05或P<0.01）。相关分析结果显示,血清总胆红素、直接胆红素及间接胆红素与血浆总胆固醇、甘油三酯、低密度脂蛋白胆固醇和脂蛋白（a）均呈负相关（P<0.05或P<0.01）,与高密度脂蛋白胆固醇均呈正相关（均P<0.05）。Logistic回归分析表明血清总胆红素与冠心病的发生独立负相关（OR=0.907,P=0.031）。结论:低胆红素血症对脂质代谢产生不利影响,可能是冠心病一项新发现的独立危险因素。Objective: To explore the association of serum bilirubin with atherosclerosis. Methods: 92 patients with coronary heart disease (CHD) determined by angiography and 68 control subjects without CUD were included in this study, and serum total bilirubin, direct bilirubin, and indirect bilirubin were measured. Results: Serum levels of total bilirubin, direct bilirubin, and indirect bilirubin in patients with multiple-vessel disease were significantly decreased compared with those in patients with single-vessel disease and control subjects (P<0.05 and P<0.01, respectively). Three parameters of bilirubin in patients with single-vessel disease were markedly lower than that in control group (P<0.05 and P<0.01,respectively). There was a negative correlation between total bilirubin, direct bilirubin, indirect bilirubin and TC, TG, LDL-C and Lp (a), and a positive correlation with HDL-C (P<0.05 and P<0.01, respectively). There was a negative correlation between total bilirubin and the occurrence of CHD analyzed by logistic regression (OR = 0.907, P = 0.031). Conclusion: Low level of serum bilirubin is an independent risk factor for CHD, and affects the metabolism of lipid unfavorably.

关 键 词：血清 胆红素 冠状动脉病变 危险因素 冠心病 

分 类 号：R541.4[医药卫生—心血管疾病]