盐酸克林霉素乳膏剂的研制和质量控制  

PREPARATION AND STANDARD OF CLINDAMYCIN HYDROCHLORIDE CREAM

作　　者：刘韵琪[1] 陈海燕 胡敢[1] 李行初[3] 魏必荣 赵春景[1] 

机构地区：[1]重庆医科大学附属二院,重庆400010 [2]重庆市药品检验所,重庆400015 [3]重庆市第一人民医院药剂科,重庆400011

出　　处：《华西药学杂志》2002年第3期211-212,共2页West China Journal of Pharmaceutical Sciences

摘　　要：目的　建立克林霉素乳膏剂的制备方法和质量标准。方法　采用HPLC测定盐酸克林霉素含量。结果　该法能很好分离被测组分与其它杂质 ,线性范围 5～ 2 5 0 0 μg(r =0 .9985 ) ,平均回收率 98.72 % ,RSD =1.5 2 %。结论此工艺简单 。OBJECTIVE To establish the preparation process and quality standard for clindamycin hydrochloride cream. METHODS Clidamycin hydrochloride in cream was deterined by HPLC.RESULTS The linear range of clindamycin hydrochloride was 5～2500 μg(r=0.9985),The average recovery was 98.72%(RSD=1.52).CONCLUSION The clindamycin hydrochloride cream is stable,the method of quality control is simple and reliable.

关 键 词：盐酸克林霉素乳膏剂 研制 质量控制 制备 

分 类 号：R978.1[医药卫生—药品] R944.21[医药卫生—药学]