示波计时电位法测定环丙沙星的含量  

DETERMINATION OF CIPROFLOXACIN BY OSCILLOGRAPHIC CHRONOPOTENTIOMETER

作　　者：胡娟[1] 王宏[1] 

机构地区：[1]华中科技大学化学系,湖北武汉430074

出　　处：《华西药学杂志》2002年第3期213-214,共2页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金 (批准号 :2 9775 0 18);河南省教育厅自然科学基础研究项目 ( 2 0 0 0 5 30 11)资助课题

摘　　要：目的　测定环丙沙星 (片、胶囊、注射液 )的含量。方法　用示波计时电位法 ,于pH 6 5KCl-H3 BO3 -NaOH底液中 ,通过测量环丙沙星在示波图上所产生切口的高度 ,根据与浓度成正比的关系 ,用标准曲线法进行定量分析。结果　质量浓度在 15～ 12 0mg·L-1内 ,与切口高度呈良好线性关系 ,r =0 9998,回收率为 99 0 6 % ,RSD=2 3%。结论　示波法测定过程干扰小 。OBJECTIVE To establish a method for determining ciprofloxacin preparations.METHODS In buffer solution pH=6.5 KCI-H 3BO 3-NaOH,a sensitivity incision due to the redox reaction of ciprofloxacin was observed on the dE/dt-E oscillogram,the incision height was linearly proportional to the drug concentration. RESULTS The linear range is 15.0～120 mg·L -1,the average recovery was 99.06% and RSD=2.3%,respectively. CONCLUSION This apparatus is simple with convenient operating and no interference was found.It can be used to control drug quality.

关 键 词：示波计时电位法 含量测定 环丙沙星 

分 类 号：R978.19[医药卫生—药品] R927.2[医药卫生—药学]