光和热对诺氟沙星注射液稳定性的影响  

EFFECT OF LIGHT AND HEAT ON THE STABILITY OF NORFLOXACIN INJECTION

作　　者：李琳丽[1] 詹先成[1] 姚德蛟[2] 祝小元[1] 涂莉[1] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]成都中医药大学,四川成都610072

出　　处：《华西药学杂志》2002年第3期168-170,共3页West China Journal of Pharmaceutical Sciences

基　　金：国家自然科学基金资助项目 (批准号 :39770 882 )

摘　　要：目的　探讨光和热同时对诺氟沙星注射液稳定性的影响。方法　采用在高温下进行光照试验的方法。结果　该药物在恒温避光加速试验或高温下光照试验中的降解均遵从零级动力学规律。结论　在高温和光照同时作用下的降解速率常数ktotal由两部分构成 :ktotal=kdark+klight,kdark和klight分别为避光时热反应的降解速率常数及光化反应的降解速率常数 ,且klight=Alight×exp(-Ea ,light/RT)·E。OBJECTIVE To study the effect of both light and heat on the stability of Norfloxacin injection. METHODS The accelerated tests upon exposure to light at high temperatures were employed. RESULTS The degradation of Norfloxacin injection in isothermal heating experiments or the exposure experiments to light at high temperatures obey zero order kinetics. CONCLUSION The total degradation rate constant k total caused by both light and heat can be divided into two patrs:k total=k dark+k light,where k dark and k aight are the degradation rate constant caused by heat and light,respectively.The k light can be expressed as k light=A light·exp(-E a,light/RT)·E, where E is the illuminance of light; E a,light and A light are experimental constants related to the light sources.

关 键 词：热稳定性 诺氟沙星注射液 光稳定性 光源 

分 类 号：R978.19[医药卫生—药品] R927.11[医药卫生—药学]