盐酸去氢骆驼蓬碱胶囊兔体内药物动力学及生物利用度研究  

Study on pharmacokinetics and bioavailability of harmine hydrochloride capsules in rabbits

作　　者：王长虹[1] 高炜玮[1] 孙殿甲[1] 

机构地区：[1]新疆医科大学药学院药剂教研室,新疆乌鲁木齐830054

出　　处：《西北药学杂志》2002年第3期115-117,共3页Northwest Pharmaceutical Journal

摘　　要：目的　研究盐酸去氢骆驼蓬碱胶囊在兔体内的药物动力学及其生物利用度。方法　采用反相高效液相色谱法测定家兔血浆药物浓度。结果　家兔灌胃给盐酸去氢骆驼蓬碱胶囊后血浆药物浓度在 4.73 h左右达峰值(1 .5 2 7mg· L-1) ,消除半衰期为 4.73 h,灌胃给胶囊剂的生物利用度为 1 7.1 4%。结论　家兔灌胃给盐酸去氢骆驼蓬碱吸收迅速 。Objective To study the pharmacokinetics and bioavailability of harmine hydrochloride capsules in rabbit. Method The blood samples was collected for 8 h after injection of harmine hydrochloride iv or ig administration. The concentrations of harmine hydrochloride in plasma were measured by RP-HPLC. Results The drug peak level in plasma reached at about 0.68 h with an average value of 1.527 mg·L -1 after ig administration. The average elimination half-life was 4.73 h. The bioavailability of harmine hydrochloride capsules was 17.14%. Conclusion Harmine hydrochloride was absorbed rapidly, but with a lower bioavailability.

关 键 词：盐酸去氢骆驼蓬碱 药物动力学 生物利用度 家兔 

分 类 号：R945[医药卫生—微生物与生化药学]