慢性乙型肝炎时肝窦内皮细胞变化及其意义  

Morphological changes of sinusoidal endothelial cells in the patients with chronic hepatitis B

作　　者：郝菁华[1] 石军[1] 任万华[1] 韩国庆[1] 朱菊人[1] 王书运[2] 谢英渤[2] 

机构地区：[1]山东省立医院肝病中心,济南250021 [2]山东师范大学电镜室

出　　处：《中华传染病杂志》2002年第3期160-163,共4页Chinese Journal of Infectious Diseases

基　　金：山东省科委资助项目 ( 9812 16 511)

摘　　要：目的　观察慢性乙型肝炎肝组织窦内皮细胞 (SEC)的形态学改变 ,探讨其与肝脏微循环障碍的关系。方法　对 5 3例慢性乙型肝炎患者进行肝脏活检术 ,肝脏活检组织分别进行光镜和电镜观察。结果　慢性肝炎患者SEC发生了很大变化 ,主要表现在窗孔减小、减少 ,SEC下基底膜形成 ,SEC间出现细胞连接 ,SEC胞质内出现WP小体及SEC脱落现象。随慢性乙型肝炎病变程度加重 ,SEC形态改变愈为显著。SEC与淋巴细胞、库普弗细胞之间亦发生了密切接触。结论　慢性乙型肝炎肝组织的SEC形态上发生了很大变化 。Objective To observe the morphological changes of sinusoidal endothelial cells(SECs) in the patients with chronic hepatitis B, and to study the relationship between the SECs changes and the development of hepatic microcirculation disorders. Methods The liver biopsy tissues from fifty three cases with hepatitis B were observed with light microscope and transmitted electronic microscope. Results The morphologies of SECs in patients with chronic hepatitis B changed significantly. The main manifestations included decreased sizes and reduced numbers of penestrate on SECs, basal membrane formation, cellular connection development between SECs, occurrence of WP bodies in SECs and the disappearance of SECs. The intimate contact occurred between SEC and lymphocyte or Kupffer cell. Conclusions The morphologies of SECs in patients with chronic hepatitis B develop significant change, which might be the initial step in the development of hepatic microcirculation disturbances.

关 键 词：肝窦内皮细胞 微循环 Weibel-Palade小体 慢性乙型肝炎 形态学改变 

分 类 号：R512.6[医药卫生—内科学]