北京降压0号与氨氯地平治疗原发性高血压的临床对比试验  

Comparison of Beijing Anti-hypertension 0 and Amlodiping in Treatment Essential Hypertension

作　　者：孙宁玲[1] 吴彦[1] 洪昭光[2] 谢英[2] 崔亮[3] 赵秀丽[3] 刘国树[4] 谢晋湘[5] 刘丽芳[5] 王海燕[6] 张金枝[7] 程龙献[7] 黄永麟[8] 吴印生 何桂英[10] 

机构地区：[1]北京大学人民医院,北京100044 [2]北京安贞医院,北京100029 [3]北京市朝阳医院,北京100020 [4]解放军总医院,北京100853 [5]北京阜外医院,北京100037 [6]南京医科大学第一医院,南京210029 [7]华中科技大学同济医学院协和医院,武汉430022 [8]哈尔滨医科大学第二医院,哈尔滨150001 [9]江西医科大学第一医院,南昌330006 [10]陕西省人民医院,西安710068

出　　处：《中国临床药理学杂志》2002年第3期171-173,共3页The Chinese Journal of Clinical Pharmacology

摘　　要：目的:评价北京降压0号片剂治疗轻中度原发性高血压患者的降压疗效 和药物不良反应。方法:采用多中心随机双盲对照研究,设苯磺酸氨氯地平为 对照药物。结果:入选病人共216例,降压0号组110例,氨氯地平组106例。与 治疗前比较,降压0号组收缩压和舒张压分别下降14.4％和18.2％（P<0.001）,氨 氯地平组分别为13.2％和15.6％（P<0.001）,均有统计学意义。舒张压下降幅度的 均值在降压0号组17.95±7.19mmHg,氨氯地平组15.52±7.59mmHg（P<0.05）,治　疗后血压降为正常水平者（<130/80/85mmHg）在降压0号组40.9％、氨氯地平组26.4％（P<001）。降压0号组和氨氯地平组发生药物不良反应的比例分别为8.9％和5.6％,无统计学显著性差异（P>0.05）。但降压0号组血小板减少6.7％（P<0.01）和　肌酐升高10.7％（P<0.001）具有统计学显著性意义。结论:北京降压0号每日服用一次,可以显著地、平稳地降低血压,无严重药物不良反应。OBJECTIVE: To Study the effect and safety of Beijing Anti-hypertension No. 0 in treatment of essential hypertension. METHOD: multicenter,double-blind, randomized, and amlodipine-controlled strudy. RESULTS: 216 patients, group A BEIJING Anti-hypertension No. 0 110 patients, group B(amlodipine) 106 patients completed the study. After treatment, systolic and diastolic pressure decreased 14.4% and 18.2%(P<0.001) in group A, 13.2% and 15.6% in group B(P<0.001), all of them have statistical significance, distolic pressure decreased more in group (17.95± 7.19mmHg) than group B (15.52±7.59mmHg)(P<0.05). The patients with the blood pressure decreased to normal (<135/85mmHg) were more in group A (40.9%) than in group B(26.4%)(P<0.05). The adverse events in group A and group B are 8.9% and 5.6%, P>0.05 . No severe side effect occurred. But the patients treated with Beijing Anti-hypertension No. 0 had mild decrease (6.7%, P<0.01) in platelet and increase in creatinine(10.7%, P<0.001). CONCLUSION: Beijing Anti-hypertension No. 0 once daily can remarkably reduce blood pressure and no severe adverse reactorl occurred.

关 键 词：北京降压0号 氨氯地平 治疗 原发性高血压 

分 类 号：R544.105[医药卫生—心血管疾病] R972.4[医药卫生—内科学]