5-氨基-2,4,6-三碘异酞酸的合成  

Study of Synthesizing 5-Amino-2,4,6-Triiodoisophthalic Acid

作　　者：王飞镝[1] 崔英德[1] 邓旭忠[1] 邱清华[2] 宋晓锐[1] 方岩雄[1] 

机构地区：[1]广东工业大学轻工化工学院,广州510090 [2]华南理工大学材料学院,广州510640

出　　处：《中国现代应用药学》2002年第3期214-215,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :合成非离子含碘造影剂的中间体 5 -氨基 - 2 ,4,6 -三碘异酞酸。方法 :以间苯二酸为原料 ,经硝化、还原与碘化 ,合成 5 -氨基 - 2 ,4,6 -三碘异酞酸。结果 :每步均经改进 ,总收率达 5 0 .2 % ,所得产品熔点、IR、1HNMR、13CNMR光谱数据 ,与文献报道一致。结论 :本工艺路线方法简单 ,原料易得 ,易工业化生产。OBJECTIVE:To synthesize 5 amino 2,4,6 triiodoisophthalic acid, the intermedia of nonionic iodinated X ray contrast agents. METHOD:With the isopthalic as the starting material, 5 Amino 2,4,6 triiodoisophthalic acid was synthesized from isophthalic acid by a three step procedure, nitration, reduction and iodination.RESULTS:Each step was modified and improved. The overall yeilds was 50.2%. The melting point and IR? 1HNMR? 13 CNMR of the product prepared were identical to that of the reported one.CONCLUSION:The process can be easily controlled and is suitable for a scale production.

关 键 词：5-氨基-2 4 6-三碘异酞酸 合成 造影剂 药物中间体 

分 类 号：TQ460.4[化学工程—制药化工]