西立伐他汀和普伐他汀治疗高胆固醇血症患者疗效比较  

The Efficacy of Cerivastatin in comparsion with pravastatin in treatment of hypercholesterolemia

作　　者：薛兆利[1] 李明智[1] 孙晓霞 孙士春[1] 朱军[2] 

机构地区：[1]山东菏泽医学专科学校,菏泽274030 [2]复旦大学华山医院,上海200040

出　　处：《中国现代应用药学》2002年第3期232-233,共2页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的 :探讨西立伐他汀及普伐他汀对高胆固醇血症患者疗效及安全性。方法 :15 0例高胆固醇血症患者随机分为两组 :西立伐他汀组 75例和普伐他汀组 75例 ,治疗 8周后观察血脂变化和安全性 ,并加以比较。结果 :两种药物均可显著降低总胆固醇 (TC) ,血甘油三酯 (TG) ,低密度脂蛋白 胆固醇 (LDL C) ,并可升高高密度胆蛋白 胆固醇 (HDL C) ,而两药的不良反应无显著差异。结论 :西立伐他汀具有显著的降脂作用 ,在调脂的同时并可抑制血小板活性 ,改善胰岛素抵抗。OBJECTIVE:To study clinical efficacy and safety of cerivastatin and pravastatin on hypercholesterolemia.METHOD:150 hypercholesterolmia patients were divided into cerivastin group ( n =75) and pravastatin group ( n =75).The lipid and safety was study after 8 weeks. RESULTS:Both agents significantly reduced TC,TG,LDL C,and increased HDL C.No significant difference in side effect incidence between agents was obseveved.CONCLUTION:Cerivastatin is effective to treat hypercholesterolemia by inhibiting the platelet activity and improving the insulin resistance.

关 键 词：西立伐他汀 普伐他汀 高胆固醇血症 治疗 疗效比较 

分 类 号：R972.6[医药卫生—药品] R589.2[医药卫生—药学]