有氧运动训练对增龄小鼠线粒体DNA缺失的影响  

Effects of Aerobic Training on Mitochondrial DNA Deletion in Aging Mice

作　　者：陈彩珍[1] 卢健[1] 

机构地区：[1]广州体育学院体育科学研究所,广州510075

出　　处：《中国运动医学杂志》2002年第4期364-366,共3页Chinese Journal of Sports Medicine

摘　　要：应用PCR技术 ,检测小鼠心肌、骨骼肌、肝脏、肾脏和大脑等组织mtDNA的缺失 ,探讨衰老及有氧运动训练延缓衰老的可能机制。结果发现 ,老年小鼠各组织mtDNA 3 866bp片段缺失发生率高于青年鼠。在所测的五种组织中肝脏mtDNA的缺失比例最低 ,大脑最高 ,说明衰老线粒体的功能下降是多系统的 ,但程度表现不均衡。长期有氧运动训练可显著减少 3 866bp片段缺失在心肌及骨骼肌中的积累 ,但肾脏mtDNA片段缺失有增多趋势 ,提示运动训练可能通过提高机体心肌、骨骼肌抗氧化应激能力 ,降低自由基影响 ,进而保护mtDNA。The mtDNA deletion were investigated in mice heart, liver, brain, kidney and skeletal muscle by PCR to study the mechanism of aging. The results showed that the mtDNA deletion appeared subsequently accumulated with aging, mtDNA deletion reached a maximum in brain and a minimum in liver. The 3866bp deletion was dramatically decreased in heart and skeletal muscle of trained mice. It suggested that long-term aerobic training contribute to a slower decline of age-related functional ability and may prevent or delay the onset of degenerative disease.

关 键 词：有氧运动训练 小鼠 线粒体 DNA缺失 PCR 衰老 小鼠 

分 类 号：G806[文化科学—运动人体科学]