辛伐他汀对大鼠实验性脂肪肝的影响  

Effect of simvastatin on experimental liver steatosis in rats

作　　者：丁小云[1] 李定国[2] 徐芹芳[2] 陆汉明[2] 

机构地区：[1]宁波市第一医院消化科,浙江省宁波市315010 [2]上海第二医科大学新华医院消化科,上海市200092

出　　处：《世界华人消化杂志》2002年第6期650-653,共4页World Chinese Journal of Digestology

摘　　要：目的:观察辛伐他汀对大鼠实验性脂肝的影响。 方法:制备大鼠实验性脂肪肝模型;观察大鼠肝组织病理学变化;测定肝组织脂质过氧化物丙二醛和甘油三酯含量以及血清生化学指标。 结果:辛伐他汀治疗组大鼠肝组织脂肪肝形成程度减轻,肝细胞质内脂滴明显减少;肝组织甘油三酯和丙二醛含量下降,大剂量组为51.2±10mg/g和460±172nmol/L,小剂量组为49.2±3.5mg/g和502±160nmol/L,低于模型组的65.5±9.4mg/g和718±116nmol/L(P<0.05)。治疗组大鼠血清谷丙转氨酶较模型组降低(54.6±9U/L和55.0±7.0U/L,vs 69.0±5.5U/L,P<0.05)。AIM: To observe the effect of simvastatin on experimental liver steatosis in rats induced by alcohol and high fat diet.METHODS: Alcohol and high fat diet were used for 7 weeks to induce fatty liver in rats. The liver tissue was studied with light and electron microscope as well as immunohistochemistry. MDA and TG in the liver tissue and serum biochemical parameters were measured by biochemical assay.RESULTS: The rat model had developed moderate to severe liver steatosis histologically The hepatocytic cytoplasm became filled with tinny lipid droplets under microscope. But no obvious collagen fiber was deposited in the liver tissue. As compared with the model rats, liver steatosis in the rats treated with simvastatin was less in degree. The contents of MDA and TG in the liver tissue were significantly reduced (51.2 ± 10 mg/g and 460 ± 172 nmol/L as well as 49.2 ±3.5 mg/g and 502 ± 160 nmol/L) in the two treatment groups respectively, which were lower than 65.5 ± 9.4 mg/g and 718± 116 nmol/L in the model group ( P < 0. 05). Moreover, serum levels of AST in the treatment groups were decreased as compared with the model group(54.6 ± 9 U/L and5.0±7.0U/L vs69.0±5.5 U/L, P<0.05).CONCLUSION: Simvastatin can prevent the development of the experimental liver steatosis in the rats.

关 键 词：辛伐他汀 大鼠 脂肪肝 影响 放射免疫法 脂质代谢紊乱 

分 类 号：R965[医药卫生—药理学]