氯化钠对高血压大鼠循环及组织血管紧张素Ⅱ的影响  

Effects of Salt on Levels of Angiotensin Ⅱ in Plasma and Tissues

作　　者：徐秀英[1] 黄燕[2] 汪家瑞[2] 

机构地区：[1]首都医科大学附属北京天坛医院心内科 [2]首都医科大学宣武医院心内科

出　　处：《首都医科大学学报》2002年第2期139-141,共3页Journal of Capital Medical University

摘　　要：观察了氯化钠对自发性高血压大鼠 (spontaneouslyhypertensiverats,SHR)循环及组织血管紧张素Ⅱ (an giotensinⅡ ,AngⅡ )的影响。 2 0只雄性 8周龄SHR配对分为高氯化钠组和对照组 (均n =1 0 ) ,分别给予 2 %氯化钠和清水喂养 6周 ,用放射免疫法测定血浆肾素活性 ( plasmareninactivity,PRA)、血浆和组织血管紧张素Ⅱ。结果 :高氯化钠组PRA为 ( 1 .1 3± 0 .72 )ng/(mL·h) ,较对照组〔( 1 .94± 0 .96 )ng/(mL·h)〕明显下降 (P <0 .0 5 ) ,血浆AngⅡ为 ( 89.4± 1 .4 )ng/L ,较对照组〔( 1 1 1 .6± 1 .3)ng/L〕略有下降 ,但无统计学意义 (P >0 .0 5 ) ,高氯化钠组的心脏、血管AngⅡ水平较对照组升高 ,分别为 ( 2 2 7.1± 1 .1 )pg/g比 ( 1 5 1 .4± 1 .1 ) pg/g,P <0 .0 1 ,( 5 7.1± 1 .5 ) pg/g比 ( 30 .7±2 .0 )pg/g ,P <0 .0 5 ;肾脏AngⅡ水平 2组间无差异 (P >0 .0 5 )。提示氯化钠负荷对循环及组织AngⅡ的影响是不同的。To investigate the effects of salt on the levels of angiotensin Ⅱ(AngⅡ) in plasma and tissues in spontaneously hypertensive rat(SHR), twenty 8-week-old male SHRs were divided into experimental and control groups(n=10). They were given 2% NaCl and distilled water respectively for 6 weeks. Plasma renin activity (PRA) and AngⅡ levels were measured by radioimmunoassays. Results showed that PRA in experimental group was decreased(1.13±0.72) ng/(mL·h) vs (1.94±0.96) ng/(mL·h, P<0.05) and plasma AngⅡ had a slight decrease but no significant difference 〔(89.4±1.4) ng/L vs (111.6± 1.3 ) ng/L, P>0.05〕 compared with the control. AngⅡ levels increased in heart and artery in the experimental group 〔(227.1±1.1) pg/g vs (151.4±1.1) pg/g, P<0.01, (57.1±1.5) pg/g vs ( 30.7 ±2.0) pg/g, P< 0.05〕, AngⅡ levels in kidney appeared to be no significant difference between two groups. The experiment indicates that circulatory and tissue renin-angiotension-system response to salt was different in SHR.

关 键 词：氯化钠 自发性高血压 大鼠 组织血管紧张素Ⅱ 放射免疫法 肾素血管紧张素 

分 类 号：R544.1[医药卫生—心血管疾病]