大黄虫丸对难治性肾病综合征Ⅷ因子抗原及纤维蛋白原的影响  

Effects of Da-Huang-Zhe-Chong Pills on the Ⅷ Factor Antigen and Fibrinogen in Idiopathic Membrane Nephritic Syndrome Sases

作　　者：魏连波[1] 马志刚[1] 李玉明 黄璜[1] 栾图[2] 叶任高[3] 

机构地区：[1]第一军医大学南方医院,广州510515 [2]广州市博爱医院 [3]中山医科大学肾脏病研究所

出　　处：《浙江中西医结合杂志》2002年第7期399-401,共3页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的 :探讨大黄虫丸对特发性膜性肾炎 ( MGN)肾病综合征 ( NS) 因子抗原 ( R:Ag)、纤维蛋白原 ( Fbg)的作用。方法 :选择 MGN— NS患者 60例 ,用美国 IL公司生产 ACT- 2 0 0自动凝血机检测 R:Ag、Fbg的变化。并随机分为治疗组和对照组 ,治疗组用大黄虫丸 ,对照组用潘生丁干预治疗。观察大黄虫丸对 MGN- NS患者血 R:Ag、Fbg的影响。结果 :实验组 R:Ag、Fbg水平较正常对照组显著增高 ( P<0 .0 0 1 ) , R:Ag、Fbg与 BUN呈显著正相关 ( P<0 .0 0 1 ) ,Fbg与白蛋白 ( ALB)呈显著负相关 ( P<0 .0 1 )。经用大黄虫丸治疗后 ,MGN- NS患者血 R:Ag、Fbg显著降低 ( P<0 .0 1 ,P<0 .0 5 ) ,明显优于潘生丁 ( P<0 .0 5 )。结论 :大黄虫丸能显著降低 MGN- NS患者 R:Ag、Fbg含量 ,改善高凝状态。Objective: To explore the effects of Da Huang Zhe Chong pills on the Ⅷ factor antigen and fibrinogen in idiopathic membrane nephritic syndrome(MGN NS) cases.Methods:60 MGN NS cases were divided at random into 2 groups:Treatment group(treated with Da Huang Zhe Chong pills) and control group (treated with agacore) to study the changes of ⅧR Ag and fibrinogen by using ACT 200 auto blood coagulation machine made in USA.Results: ⅧR Ag and fibrinogen in treatment group case were significantly reduced after the treatment( P <0.01), which was better than the control group cases ( P <0.05). Conclusion:Da Huang Zhe Chong pills could reduce the ⅧR Ag and fibrinogen and improve the blood coagulation state.

关 键 词：大黄Zhe丸 难治性肾病综合征 Ⅷ因子抗原 纤维蛋白原 高凝状态 

分 类 号：R692[医药卫生—泌尿科学]