[2-(2-羟基苯基)亚氨甲基苯硫酚根(2-)-N,O,S](2-甲氧羰基乙基-C,O)氯化锡的合成及性质  

Synthesis and Properties of [2-(2-Hydroxyphenyl)iminomethyl- [JZ]benzenethiolato(2-)-N,O,S](2-methoxy-(2-methoxy-carbonylethyl-C,O)tin Chloride

作　　者：田来进[1] 周正宇[1] 

机构地区：[1]曲阜师范大学化学系

出　　处：《高等学校化学学报》2002年第7期1231-1235,共5页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 0 0 75 0 16);晶体材料国家重点实验室开放基金;曲阜师范大学科研基金资助

摘　　要：利用 2 -甲氧羰基乙基三氯化锡与硫代水杨醛缩邻氨基苯酚 (H2 L)进行反应合成了标题配合物 [2 -(2 -羟基苯基 )亚氨甲基苯硫酚根 (2 -) -N,O,S](2 -甲氧羰基乙基 -C,O)氯化锡 CH3OCOCH2 CH2 Sn Cl L(L=2 -SC6 H4 CH NC6 H4 O-2 ) ,该配合物与二甲基亚砜 (DMSO)、六甲基磷酰胺 (HMPA)等单齿配体反应生成混配配合物 CH3OCOCH2 CH2 Sn Cl LL′(L′=DMSO,HMPA) ,与醇 (ROH)反应生成相应的 2 -烷氧羰基乙基锡配合物 ROCOCH2 CH2 Sn Cl L.通过元素分析、红外光谱、核磁共振谱等对配合物的结构进行了表征 .用 X射线单晶衍射测定了标题配合物的晶体结构 ,晶体属三斜晶系 ,P1空间群 ,Z=2 ,晶胞参数 a=0 .870 4(2 )nm,b=0 .93 93 (3 ) nm,c=1 .45 1 1 (3 ) nm,α=98.0 5 (3 )°,β=1 0 3 .0 3 (3 )°,γ=96.99(3 )°.该配合物具有分子内羰基氧原子和配体 L的硫、氮、氧原子对锡原子配位的畸变八面体结构 .The title complex,[2 (2 hydroxyphenyl)iminomethyl benzenethiolato(2 ) N,O,S] (2 methoxycarbonylethyl C,O) tin chloride, CH 3OCOCH 2CH 2SnClL(L=2 SC 6H 4CHNC 6H 4O 2), was synthesized by the reaction of 2 methoxycarbonylethyltin trichloride with N (2 hydroxy phenyl)thiosalicylideneimine. This complex reacted with neutral monodentate ligands such as dimethylsulfoxide(DMSO) and hexamethylphosphoramide(HMPA) to form the mixed ligand complexes, CH 3OCOCH 2CH 2SnClLL′(L′=DMSO, HMPA), and also readily underwent transesterification with alcohols to produce the corresponding 2 alkoxycarbonylethyltin analogues, ROCOCH 2CH 2SnClL. These complexes were characterized by means of elemental analysis, IR and 1H NMR spectra. The crystal structure for the title complex was determined by X ray diffraction analysis. The crystal belongs to triclinic system, space group P 1 with cell parameters a =0.870 4(2) nm, b =0.939 3(3) nm, c =1.451 1(3) nm, α =98.05(3)°, β =103.03(3)°, γ =6.99(3)°, V =1.129 9(4) nm 3, Z=2, D c=1.378 g/cm 3, F (000)=524 . In this compound, the tin atom adopts a distorted octahedral geometry via intramolecular carbonyl oxygen atom and the sulfur, nitrogen and oxygen atoms of the chelating ligand L to tin coordination.

关 键 词：合成 性质 锡(Ⅳ)配合物 硫代水杨醛缩邻氨基苯酚 2-甲氧羰基乙基三氯化锡 晶体结构 结构 抗癌药物 

分 类 号：TQ462.4[化学工程—制药化工] O614.432[理学—无机化学]