3,11(13)-二烯-12-桉烷酸的立体选择性全合成  

Enantioselective Total Synthesis of 12-Carboxyeudesma-3,11(13)-diene

作　　者：周罡[1] 陈永刚[1] 关玉昆[1] 郑国君[1] 李裕林[1] 

机构地区：[1]兰州大学应用有机化学国家重点实验室,有机化学研究所兰州73000

出　　处：《高等学校化学学报》2002年第7期1324-1326,共3页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金 (批准号 :2 973 2 0 60 )

摘　　要：The enantioselective total synthesis of 12 carboxyeudesma 3,11(13) diene(1) was achieved starting from(-) dihydrocarvone in ten steps for the first time. The key steps mainly include the introduction of hydroxyl group into C 12 position of eudesmane by Vilsmeier chlorination and the generation of C3-C4 double bond into the eudesmane skeleton by elimination of halide.The enantioselective total synthesis of 12 carboxyeudesma 3,11(13) diene(1) was achieved starting from(-) dihydrocarvone in ten steps for the first time. The key steps mainly include the introduction of hydroxyl group into C 12 position of eudesmane by Vilsmeier chlorination and the generation of C3-C4 double bond into the eudesmane skeleton by elimination of halide.

关 键 词：立体选择性全合成 3 11(13)-二烯-12-桉烷酸 不对称全合成 (一)-二氢香芹酮 植物药 

分 类 号：R284.3[医药卫生—中药学]