背向散射技术与彩色室壁运动技术评价慢性冠状动脉狭窄存活心肌的实验研究  

Animal study of the value of integrated backscatter and color kinesis on viable myocardium of swine with chronic coronary artery stenosis

作　　者：吴文霞[1] 陆凤翔[1] 许迪[1] 陈莉[1] 雍永宏[1] 周蕾[1] 丁建东[1] 徐国会[2] 励建安[2] 陈亦江[3] 施海彬[4] 

机构地区：[1]南京医科大学附属第一医院心内科,210029 [2]南京医科大学附属第一医院康复医学科,210029 [3]南京医科大学附属第一医院胸外科,210029 [4]南京医科大学附属第一医院放射科,210029

出　　处：《中华超声影像学杂志》2002年第6期356-360,共5页Chinese Journal of Ultrasonography

摘　　要：目的　研究超声背向散射及彩色室壁运动技术对猪慢性冠状动脉狭窄、侧支循环形成后存活心肌的检出价值。方法　健康小型猪 10只 ,开胸放置Ameroid缩窄器 ,分别于手术前、术后 1d、3d、1周、2周、3周、4周利用超声背向散射、彩色室壁运动技术采集胸骨旁长轴、乳头肌短轴、心尖四腔、两腔观的标准切面图像 ,术前、术后 1周、2周、3周、4周进行冠状动脉造影 ,4周处死动物行病理检查。结果　除1只猪由于技术原因被剔除外 ,其余 9只均成功地建立了慢性冠状动脉狭窄侧支循环模型 ;术后 3d时背向散射积分值 (IBS % )升高 ,背向散射积分周期变化 (CVIB % )降低 ,1周时变化最明显 ,4周时未恢复至正常 ;而术后 3d左室后壁增厚率 (ΔT % )降低 ,室壁运动积分指数 (WMSI)升高 ,1周变化最明显 ,至 4周时与术前相比仍有明显差异 (P <0 .0 5 )。结论　背向散射与彩色室壁运动技术可以检出猪慢性冠状动脉狭窄、侧支循环形成后的存活心肌。Objective To assess the value of ultrasonic tissue characterization with integrated backscatter(IBS) and color kinesis (CK) on viable myocardium of swine with chronic coronary artery stenosis and collateral circulation development.Methods Ten swine were performed with thoracotomy and pericardiectomy. Ameroid constrictor was then implanted around the left circumflex artery (LCX) proximal to the first marginal branch. Ecocardiography study (including IBS, CK and two dimension) were performed pre operation and 1 day,3 day,1 week,2 week,3 week, 4 week after operation, respectively;coronary angiography was performed to evaluate the degree of stenosis,collaterals and myocardial function pre operation and post 1 week,2 week,3 week and 4 week after operation, and pathological examinations were performed post 4 week after operation.Results Nine swine were successfully found the development of collateral circulation, 4 week after surgery integrated backscatter parameters didn't restore to the values before surgery, while wall motion score index(WMSI) and the percentage of wall thickening (ΔT%) 4 week after surgery were also significantly different from the values before surgery. Conclusions IBS and CK may detect viable myocardium of swine with chronic coronary artery stenosis and collateral circulation development.

关 键 词：实验研究 冠状动脉 侧支循环 存活心肌 背向散射 彩色室壁运动 心肌疾病 

分 类 号：R445.1[医药卫生—影像医学与核医学]