糖尿病患者血浆神经肽Y放射免疫分析  

Measurement of Plasma Neuropeptide Y Levels with RIA in Diabetic Patients

作　　者：程光华[1] 张新路[1] 杨军[1] 

机构地区：[1]皖南医学院弋矶山医院核医学科,241001

出　　处：《放射免疫学杂志》2002年第3期139-140,共2页Journal of Radioimmanology

摘　　要：目的 :为探讨血浆神经肽Y(NPY)含量与糖尿病及其并发症之间的关系。方法 :6 7例非胰岛素依赖型糖尿病患者包括无血管并发症者 3 8例 (A组 )、伴肾及眼底血管病变 2 9例 (B组 ) ,分别测定患者血浆NPY水平的变化 ,同时测定了 3 7例正常人血浆NPY的含量。结果 :糖尿病A组、B组血浆NPY含量均较对照组升高 (p <0 0 0 1 ) ;B组明显高于A组 (p <0 0 0 1 )。结论 :血浆NPY水平的变化可能与糖尿病的发生。Objective To investigate the clinical significance of the levels of plasma neuropeptide Y(NPY) in NIDDM patients with the occurrence of vascular complications. Methods The plasma NPY levels were measured in 67 cases with DM (Group A: no Vascular complication, n=38, Group B: with renal and retinal Vascular Changes, n=29) and 37 normal subjects by radioimmunoassay. Results NPY levels were higher in diabetic patients than those in normal subjects ( p <0 001). Also the plasma NPY levels were higher ( p <0 001) in diabetic patients with angiopathy (29 cases) than in those without it (38 cases). Conclusion These data suggested that the changes of plasma NPY levels might be closely related to the occurence and development of camplications in DM patients.

关 键 词：放射免疫分析 糖尿病 神经肽Y 

分 类 号：R587.1[医药卫生—内分泌]