中国人心脏机械瓣置换后抗血栓的临床研究  

Clinic study of the efficacy and the safety of antithrombotic therapy in Chinese patients with prosthetic heart mechanical valves

作　　者：程远植[1] 陶凉[1] 朱晓东[1] 黄明北[1] 崔敏[1] 

机构地区：[1]武汉亚洲心脏病医院,湖北武汉430022

出　　处：《心血管康复医学杂志》2002年第3期206-209,共4页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨中国人机械瓣置换后抗血栓治疗方案及不同水平的抗凝国际标准化比值(INR)的疗效及与抗凝相关事件的关系.方法:334例机械瓣置换病人,总计501病人年,4 228例次检测的INR分成INR≤1.49组(67例次),1.50～1.99组(847例次),2.00～2.59组(1 420例次),2.60～3.00组(1071例次),3.01～3.60组(254例次),>3.60组(183例次).另INR 1.8～2.0并加用阿斯匹林水溶片100mg@d-1组有386例次.观察此7组疗效,相关事件发生频率及其标准化病人年发生率.结果:重度出血仅2例,出现在INR>3.6组;中度出血36例次,与INR值、妇女年龄相关(P<0.01).血栓事件2例,其INR分别为1.2,1.56.结论:机械瓣置换后抗血栓治疗要个体化,中国人单用华法令抗凝INR 2.0～3.0和低水平的抗凝(INR 1.8～2.0)加小剂量阿斯匹林100mg@d-1的抗血栓治疗方案相关事件发生率较低,比较适合.ve: To evaluate the efficacy and the safety of antithrombotic therapy in Chinese patients with prosthetic mechanical valves. Methods: The efficacy and safety of difference international normalized ratio (INR) level of oral anticoagulant Warfarin alone and low-level oral anticoagulant therapy (INR 1. 8-2. 0) in combination with oral low dose of aspirin (100 mg/day) in patients with prosthetic mechanical valves were compared. Results: Severe hemorrhagic events only 2 cases were shown in INR>3. 6 group. The moderate hemorrhagic events were shown in 36 cases. It was related to TNR level and women with special range of age. Thromboemboli events were shown in 2 cases. their INR was 1.2, 1.5 respectively. Conclusion: The antithrombotic therapy of individual is necessary. The therapy scheme of INR 2. 0-3. 0 and a low level of oral anticoagulant (INR 1. 8-2. 0) in combination with low dose of aspirin (100mg/d) are satisfactory for antithrombotic therapy in Chinese patients with mechanical prosthetic heart valves.

关 键 词：心脏机械瓣置换 抗血栓治疗 中国人 华法令 

分 类 号：R654.2[医药卫生—外科学]