猫泛白细胞减少症弱毒冻干疫苗研制与探索最佳冻干曲线的研究  

Development of Attenuated Lyophilized Vaccine of Feline Panleukopenia and earch for the Optimum Lyophizing Curve

作　　者：李六金[1] 贾满民[2] 陈慧茹[2] 李成[3] 押宗保 李文义[1] 

机构地区：[1]第四军医大学实验动物研究中心,陕西西安710032 [2]农业部兰州生物药厂,甘肃兰州730046 [3]中国农业科学院哈尔滨兽医研究所,黑龙江哈尔滨150001 [4]陕西省兽医总站,陕西西安710000

出　　处：《中国动物检疫》2002年第7期23-25,共3页China Animal Health Inspection

摘　　要：生物制品进行冷冻干燥过程中 ,或多或少会损失一定的效价 ,可直接影响产品效力和免疫原性。本文为研制出高效价和保持期长的猪泛白细脆减少症弱毒冻干疫苗 ,为降低效价损失 ,选择出最佳冷冻干燥曲线 ,使冻干后的产品效价损失减少到最低水平。试验结果选用全程为17h的冻干曲线是科学的。An attenuated lyophilized vaccine of feline panleukopenia was developed and prepared using attenuated virus FPV1 strain.An optimum lyophilizing curve was designed to produce efficient and durable attennated FPV1 vaccine.Tests showed that 17 hours lyophilizing procedure was scientific and feasible.

关 键 词：猫泛白细胞减少症 冻干疫苗 冻干曲线 细胞培养 病毒增殖 弱毒疫苗 成品检测 

分 类 号：S858.293[农业科学—临床兽医学]