灯盏花素对豚鼠心室肌细胞迟发性外向钾电流的影响  

Effect of breviscapine on delayed outward potassium current in single ventricular cell of guinea pig

作　　者：王丽娟[1] 王勇 李金鸣[3] 

机构地区：[1]齐齐哈尔医学院药理学教研室,齐齐哈尔161042 [2]北钢医院药剂科,齐齐哈尔161041 [3]中国医科大学药理教研室,沈阳110001

出　　处：《中国药理学通报》2002年第3期326-328,共3页Chinese Pharmacological Bulletin

摘　　要：目的　观察灯盏花素对心室肌细胞迟发性外向钾离子电流的影响。方法　应用全细胞膜片钳制技术。结果　灯盏花素以剂量依赖的方式增加Ik,0 0 1g·L-1灯盏花素使Ik 增大 4 4 6 % (0 0 1<P <0 0 5 ) ,0 0 2 g·L-1灯盏花素使Ik增大 6 0 3% (P <0 0 1) ,灯盏花素此作用经冲洗可部分消退。结论　灯盏花素能促进K+ 通道开放 ,促进K+AIM To Investigate the effect of breviscapine on delayed outward potassium current in single ventricular cell of guinea pig. METHOD Using whole cell patch clamp technique. RESULTS Breviscapine enhanced I k dose dependently. Breviscapine with the concentration of 0\^01 and 0\^02 mg·L -1 increased I k by 44.6% and 78.3%,respectively. The effect could be reversed by washing. CONCLUSION Breviscapine can open the K + channel and incrase I k .

关 键 词：灯盏花素 膜片钳制技术 迟发性外向钾离子电流 Ik 

分 类 号：R332[医药卫生—人体生理学] R282.71[医药卫生—基础医学]