左旋精氨酸治疗高原肺水肿的临床研究  

Clinical study of L-arginine on high altitude pulmonary edema

作　　者：张西洲[1] 马勇[1] 王伟[1] 崔建华[1] 白虎虎[1] 王达文[1] 巫刚[1] 朱金山[1] 王海[1] 

机构地区：[1]解放军第18医院,新疆叶城844900

出　　处：《西北国防医学杂志》2002年第4期271-272,共2页Medical Journal of National Defending Forces in Northwest China

摘　　要：目的 :观察左旋精氨酸 (L -Arg)治疗高原肺水肿的临床效果。方法 :在海拔 370 0m ,静脉滴注L -Arg治疗高原肺水肿10例 ,雾化吸入L -Arg治疗 16例 ,并与吸入一氧化氮 (NO)混合气体治疗的 11例作对照。结果 :三组患者的肺部湿罗音消失时间和病程日数均无显著性差异 (P >0 .0 5 ) ,NO吸入组肺部x线阴影消失时间较L -Arg静脉注射组和L -Arg雾化吸入组缩短 ,差异非常显著 (P <0 .0 1)。结论 :静脉滴注和雾化吸入L -Arg治疗高原肺水肿疗效较好且经济、简便、无毒性 。Objective:To study curative effects of L-arginine(L-Arg)on high altitude pulmonary edema(HAPE). Methods:We treated 16 patients with HAPE by atomization inhalation L-Arg and 10 patients by intravenous L-Arg at 3 700 m,and the results were compared with 11 patients who inhaled low concentration of nitric oxide(NO).Results:There was no difference in the disappearance of moist rales time and duration of the illness in 3 groups (P>0.05). Compared with the atomization inhalation group and intravenous group,inhaling NO group could shorten the x-ray shadow(P<0.01).Conclusion:Atomization inhalation L-Arg and intravenous L-Arg is a handy way to treat HAPE without toxicity.It is worthy of further trial.

关 键 词：高原肺水肿 左旋精氨酸 一氧化氮 

分 类 号：R594.3[医药卫生—内科学] R541.63[医药卫生—临床医学]