双氯芬酸钠柔性脂质体的研究  

Study on diclofenac sodium flexible liposomes

作　　者：陈鹰[1] 汤韧[1] 郑汉平[1] 田洪淘[2] 陈翠明[2] 

机构地区：[1]广州军区武汉总医院药剂科,湖北武汉430070 [2]武汉大学药学院

出　　处：《中国药学杂志》2002年第7期513-516,共4页Chinese Pharmaceutical Journal

摘　　要：目的　研究双氯芬酸钠柔性脂质体 ,为临床新制剂的开发提供参考。方法　以逆相蒸发 超声法制备双氯芬酸钠柔性脂质体 ,并对其性态、包封率、透过率、体外透皮以及抗炎药效学进行了试验。结果　双氯芬酸钠柔性脂质体平均粒径为 81.5nm ,平均包封率为 73.12 % ;在 0 .3MPa外压作用下 ,柔性脂质体的透过速率平均达到水的 90 % ;体外透皮实验中 ,2 4h累积透皮吸收百分率Q %为 5 8.6 2 % ,优于普通脂质体和凝胶剂 ;对角叉菜胶所致的炎症有显著的抑制作用 ,比其凝胶剂作用持久。OBJECTIVE: To study diclofenac sodium flexible liposomes in order to develop a new therapeutic preparation. METHODS: Diclofenac sodium transfersomes was prepared by reverse-phase evaporation and then sonication. The appearance, embedding ratio, ratio of permeation, skin penetration in vitro and the pharmacodynamic tests were investigated respectively. RESULTS: The mean diameter of the flexible liposomes was 81.5 nm, mean embedding ratio was 73.12%. Under the pressure of 0.3 MPa, its ratio of permeation was 90% compared with water. The test in vitro showed that the accumulated penetration (Q%) of the flexible liposomes after 24h was 58.62%, more than conventional liposomes and gels. The flexible liposomes had significant anti-inflammatory effect on the inflammatory swelling induced by carrageenin, with longer action time than gels. CONCLUSION: Flexible liposomes may become a promising carrier of diclofenac sodium for clinical use.

关 键 词：双氯芬酸钠 柔性脂质体 逆相蒸发-超声法 剂型 抗炎药效学 体外透皮试验 

分 类 号：R944.9[医药卫生—药剂学] R971.1[医药卫生—药学]