二氢石蒜碱对大鼠高碳酸性脑缺氧损伤的保护作用  

Protective Effects of Dihydrolycorine on the Anoxia Brain Damage in Rat

作　　者：龚新荣[1] 张秋芳[1] 兰星莲[1] 潘龙瑞[1] 任世兰[1] 赵国举[1] 

机构地区：[1]郧阳医学院药理教研室,湖北十堰442000

出　　处：《郧阳医学院学报》2002年第2期71-72,共2页Journal of Yunyang Medical College

基　　金：湖北省自然科学基金资助No200J166

摘　　要：目的 :探讨二氢石蒜碱 (DL)对大鼠高碳酸性脑缺氧损伤的影响。方法 :将在体高碳酸性缺氧模型大鼠分为生理盐水组、尼莫地平组、DL 2 0mg/kg组和DL 40mg/kg组 ,记录并比较 4组动物停止、恢复人工呼吸后脑电图(EEG)出现、消失的时间及幅度。结果 :停止人工呼吸 2min后复氧 1 0min时EEG恢复幅度分别为 (32 .1 5± 33 .68) %、(75 .40± 1 7.1 2 ) %、(62 .50± 1 5 .81 ) %、(80 .0 0± 1 2 .2 6) % ,尼莫地平组、DL 2 0mg/kg组、DL 40mg/kg组与生理盐水组均有显著性差异 (P <0 .0 1 ) ,但尼莫地平组、DL 2 0mg/kg组、DL 40mg/kg组之间无显著性差异 (P >0 .0 5)。结论Objective To investigate the effect of dihydrolycorine on anoxia brain damage in rats. Methods The model of hyperbicarbonatemia was used by stopping respirator to record the reemerge time and recovery percentage of EEG during reoxygenation for 10 minutes. Results The recovery percentage of control, DL(20 mg/kg), DL(40 mg/kg), nimodipine group is respectively (32.15±33.68)%, (75.40±17.12)%, (62.50±15.81)%, (80.00±12.26)%, which showed that the drug administered markedly improved recovery of the amplitude of EEG after reoxygenation compared with the controls.Conclusions It suggests that DL and nimodipine protects against anoxia damage of brain in rat.

关 键 词：高碳酸性脑缺氧损伤 保护作用 二氢石蒜碱 脑缺氧 脑电图 DL 动物模型 

分 类 号：R965[医药卫生—药理学]