肺气肿CT定量分析──CT肺功能自动定量软件与手工方法的比较  

CT Quantitative Analysis of Pulmonary Emphysema: A Comparison of CT Automatic Quantitative Software with Manual Method

作　　者：张伟宏[1] 牟文斌[1] 罗松江[2] 刘玉清[3] 朱杰敏[1] 金征宇[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院放射科,北京100730 [2]安徽阜阳肿瘤医院 [3]北京阜外医院放射科

出　　处：《临床放射学杂志》2002年第7期522-526,共5页Journal of Clinical Radiology

摘　　要：目的　设计计算机自动定量肺体积和肺气肿的软件 ,并与手工定量方法进行比较。资料与方法　从肺气肿组 37例和正常组 2 0例中各随机调出 5例CT图像资料来验证软件的可行性。每一病例仅取 3个复杂层面 (主动脉弓层面、肺门层面和膈上层面 )来验证软件与 2位手工操作者定量结果有无差异。软件设有自动校正功能 ,比较正常组 2 0例CT图像校正前后各定量数值的差异。结果　 (1)显示多层面整体定量结果方面 ,计算机软件自动定量与手工操作者之间无明显差异 (P >0 .0 5 ) ,2位操作者之间的定量结果也无明显差异。 (2 )单个层面定量结果比较显示 ,在膈肌层面不同操作者测得CT值差异较大 (P <0 .0 1) ,而在肺门层面、主动脉弓层面测得的CT值无明显差异 (P >0 .0 5 )。 (3)经校正前后计算机自动定量结果无明显统计学差异。结论　自行设计的计算机自动定量分析软件可以快速准确地定量肺气肿组织 ,消除人工操作的差异 ,重复性好 。Objective To design an automatic computer software used to estimate the lung volume and the emphysema, to compare the results of computer software with that of manual method.Materials and Methods Each 5 cases were randomly selected from 37 emphysema patients and 20 healthy volunteers. Their CT images were used to validate the feasibility of the software. Three images (at aortic arch level, hilar level and supra-diaphragmatic level) from each case were selected to test the software function to see if the computer program could deal with the complex anatomy on these levels. The quantitative calculation was done by both the computer automatically and two radiologists manually. The results by the computer and by radiologists were compared. The computer software was designed with automatic correcting reading error function. After the radiologist manually corrected all section reading errors, the computer operator recalculated the lung volumes and pixel indexes. The CT sections from normal group were used to study the difference between uncorrected and corrected lung volume as well as pixel indexes. Results (1) No significant difference in CT value, section volume and pixel indexes between computer group and manual group was found (P> 0.05). (2) When each single section of supra-diaphragmatic level was compared, the difference in CT value between different operators was significant (P< 0.01), but no significant difference was found for aortic or hilar sections (P> 0.05). (3) No significant difference in CT value, lung volume and pixel was seen between corrected and uncorrected data. Conclusion The automatic quantitative analysis computer software designed by the authors can rapidly, correctly and well reproducibly quantify the lung emphysema, it can be regarded as an advanced technique for quantitative estimation of pulmonary function.

关 键 词：肺气肿 CT 定量分析 自动定量软件 手工方法 比较 肺功能 

分 类 号：R816.41[医药卫生—放射医学]