金蒲抑瘤片的药效和毒理研究  

STUDY ON PHARMACODYNAMICS AND TOXICOLOGY OF JINPUYILIUPIAN

作　　者：李伟芳[1] 韦宝伟[1] 刘宗河[2] 李茂[1] 周军[1] 饶伟源[1] 许振朝[1] 吴英德[1] 

机构地区：[1]广西中医药研究所,南宁530022 [2]广西医科大学附属肿瘤医院,南宁530021

出　　处：《广西医科大学学报》2002年第3期307-310,共4页Journal of Guangxi Medical University

基　　金：广西科技厅资助项目 (桂科技字 [1998]第 2 8号 )

摘　　要：目的 :评价金蒲抑瘤片对小鼠药效及毒性作用。方法 :用 NIH小鼠分组试验 ,接种瘤株为肉瘤 S1 80 和肝癌 H2 2 ,灌胃给药 ,观察相关指标。结果 :金蒲抑瘤片能抑制小鼠肉瘤 S1 80 和小鼠肝癌 H2 2 实体瘤的生长 ,平均抑瘤率分别为 4 3.6 %和 2 6 .2 % ;能延长腹腔积液型肝癌和 S1 80 腹腔积液型小鼠的生存时间 ,平均生命延长率分别为 6 0 .9%和 2 9.7%。并能增强免疫功能低下的荷瘤小鼠的碳粒廓清指数和半数溶血值 ,升高荷瘤小鼠的白细胞数 ,减轻环磷酰胺对小鼠白细胞的毒性 ,提高热板致痛小鼠的痛阈值。急性毒性和长期毒性试验 ,表明毒性反应低 ,使用安全。结论 :本品具有活血祛瘀 ,行气止痛 ,抑瘤减毒 。Objective: To evaluate the pharmacodynamics and toxicology of JINPUYILIUPIAN for its clinical application Methods: Vivo tests were conducted on mouse hepatic cancer H\-\{22\} of solid and ascites types, and on mouse sarcoma S\-\{180\}; tests of the immunity of mouse bearing sarcoma S\-\{180\} including carbon particle clearance method and specific hemolytic reactions were induced by chicken red blood cell in mouse, hot plate method for analgesic test, antidote tests for chemotherapeutic cyclophamide, acute and chronic toxicity tests Results: The tested tablet preparation JINPUYILIUPIAN significantly inhibited the growth of tumours S\-\{180\} and H\-\{22\} in mice with average inhibiting rates of 43 6% and 26 2% respectively, prolonged the survival time of the tested mice with average prolonging rates of 60 9% and 29 7%, increased the clearance for carbon particles and HC\-\{50\}(index for 50% haemolysis) in mice bearing tumour, increased the leukocytes and counteracted the toxic action of cyclophophamide on leukocytes, and increased the threshold of hot plate in the tested mice Acute tocicity tests showed that daily intragastric administration of 2 doses(equivalent to 832 times of clinical daily dose) of the preparation did not result in toxic reactions in tested mice, and no adverse reaction was found in the chronic toxicity tests in rats with daily dose equivalent to 107, 64 and 32 times of clinical daily dose for 14 weeks respectively Conclusion: The tested tablet preparation JINPUYILIUPIAN inhibits the growth of tumours S\-\{180\} and H\-\{22\} in mice, prolongs the survival time and enhances the immunity of tumor bearing mice, and counteracts the toxic action of cyclophophamide No adverse reaction foung was in long term administration

关 键 词：金蒲抑瘤片 药效 毒理 镇痛作用 

分 类 号：R286[医药卫生—中药学] R285[医药卫生—中医学]