NQO1酶及其被氧环境诱导表达的研究进展  

Advances in the study of NAD(P)H:Quinone Oxidoreductase and Its Induction by Cellular Oxidative Stress

作　　者：夏小俊[1] 金中初[1] 

机构地区：[1]浙江大学医学院病理生理学教研室,杭州310031

出　　处：《生理科学进展》2002年第3期225-229,共5页Progress in Physiological Sciences

基　　金：国家自然科学基金 (39970 6 4 9);浙江省自然科学基金(部分) (30 15 2 9)资助课题

摘　　要：NAD(P)H :醌氧化还原酶 1(NQO1)是真核细胞内普遍存在的一类黄素蛋白酶 ,它专性催化胞内双电子还原反应 ,能够解除醌类物质对细胞的毒害 ,从而起到保护细胞的作用。同时 ,它又能活化一些醌类抗肿瘤药物。本文综述了NQO1的基因结构、多态性、功能和活性调节 。NAD(P)H:Quinone oxidoreductase (NQO1) is a kind of flavoprotein that catalyzes the obligatory two electron reduction in eukaryotic cells. It can bioactivate certain antitumor quinone drugs as well as detoxify many xenobiotics and their derivatives, which lead to the protection of cells. This review focuses on NQO1 gene and protein structure, enzyme mechanism, activity regulation and its role in cellular redox cycling and tumor therapy.

关 键 词：NQO1酶 氧环境 诱导表达 研究进展 醌氧化还原酶1 抗氧化反应元件 生物还原剂 信号转导 

分 类 号：Q554[生物学—生物化学]