肠血管活性多肽或生长抑素抑制大鼠肠CD8^+淋巴细胞归巢  

Vasoactive Intestinal Peptide or Somatostatin Inhibits Homing of Intestinal CD8^+ Lymphocytes in Rats

作　　者：杨辉[1] 唐承薇[1] 

机构地区：[1]重庆医科大学第一附属医院消化内科,重庆400016

出　　处：《上海免疫学杂志》2002年第3期182-185,共4页Shanghai Journal of Immunology

基　　金：国家杰出青年科学基金资助项目 (3 972 5 0 12 )

摘　　要：为观察肠血管活性多肽 (VIP )及生长抑素 (SST )对大鼠肠淋巴细胞在肠相关淋巴组织归巢的影响 ,本实验将 18只大鼠随机分为三组 ,每组 6只 ,分别从股静脉输入生理盐水、VIP组或SST ,从肠系膜淋巴管插管引流淋巴液。结果显示 ,大鼠经静滴VIP或SST后 ,5h内肠系膜淋巴管淋巴细胞总数降低 (P <0 0 5 ) ;肠淋巴液量和对照组比较无显著改变 (P >0 0 5 ) ;每毫升淋巴液中细胞数降低 (P <0 0 5 )。VIP组和SST组肠淋巴液中CD8+ 细胞比例降低 (P <0 0 5 )。两实验组回肠粘膜CD8+ 细胞数降低 (P <0 0 5 )。VIP或SST能减少肠粘膜CD8+ 淋巴细胞与其他器官及系统免疫的沟通 ,也抑制从其他器官及系统免疫中归巢至肠粘膜的CD8+To observe the effect of vasoactive intestinal peptide(VIP) or somatostatin (SST) on the lymphocytes traffic in gut associated lymphoid tissues in rat, 18 rats were divided into three groups at random VIP or SST were continuously infused from femoral vein at a dose of 60 pmol / h for 7 h It was found that the lymphocytes in intestinal lymph collected in 5 hours were significantly reduced after VIP or SST administration( P <0 05) Although the volume decrease of intestinal lymph was appeared in all groups, no significant changes in lymph flow were observed in control and treated groups The percentages of CD8 + cells in intestinal lymph of rat treated by VIP or SST was markedly lower than that in control group ( P <0 05) Finally, either VIP or SST infusion reduced CD8 + cells in the small intestinal mucosa when compared with control It concludes that either VIP or SST not only reduces lymphocytes, especially CD8 + cells traffic from intestinal mucosa immune system to other organs and systemic immune system but also suppresses the homing of CD8 + lymphocytes into intestinal mucosa immune system in rats

关 键 词：肠血管活性多肽 生长抑素 淋巴细胞 归巢 

分 类 号：R392.12[医药卫生—免疫学]