非均匀恒磁场对低压缺氧小鼠学习记忆障碍的影响  

EFFECT OF NON-UNIFORM-PERMANENT MAGNETIC FIELD ON LEARNING AND MEMORY IMPAIRMENT IN HYPOBARIC HYPOXIC MICE

作　　者：沙建慧[1] 沈楠[1] 姚萍[1] 孙新奇[1] 朱芙蓉[1] 杨中万[1] 

机构地区：[1]第四军医大学吉林军医学院,吉林省吉林市132013

出　　处：《解放军预防医学杂志》2002年第3期164-166,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：目的 :探讨非均匀恒磁场N极、S极对急性低压缺氧引起的学习记忆障碍是否有改善作用。方法 :4 8只小鼠分为空白对照组、缺氧组、磁场N极 +缺氧组和磁场S极 +缺氧组。采用避暗实验法和自主活动法进行观察。结果 :(1)避暗实验表明 ,磁场N极 +缺氧组、磁场S极+缺氧组的累积错误次数 (M值 )分别为 2 .4 2± 1.0 8与 2 .5 0± 1.17;逃避潜伏期 (EL值 )分别为(71.0 8± 19.5 5 )s与 (5 3.0 0± 19.75 )s ,缺氧组M值为 (3.5 8± 1.0 8)次 ,EL值为 (32 .5 0± 11.6 0 )s ,则表明记忆成绩M值减少 (P <0 .0 1,P <0 .0 5 ) ,EL值延长 (P <0 .0 1,P <0 .0 5 ) ,且磁场N极 +缺氧组的EL值较磁场S极 +缺氧组的EL值延长 (P <0 .0 5 )。 (2 )动物自主活动测定表明 ,缺氧组、空白对照组、磁场N极 +缺氧组和磁场S极 +缺氧组的自主活动次数分别为 10 4± 2 2 .0 7、185± 4 1.15、187± 37.16、182± 2 9.13,缺氧组的明显减少 (P <0 .0 5 ) ,而经磁场处理的两组已恢复到正常水平。结论 :非均匀恒磁场的预防性治疗 ,可改善由低压缺氧造成的记忆功能损害 。Objective: To investigate the improving effect of non-uniform-permanent magnetic field on learning and memory impairment induced by hypobaric hypoxia in mice. Methods: 48 mice were divided into blank control group, hypoxia group, magnetic field pole N+hypoxia group and magnetic field pole S+ hypoxia group. The step-through test and independent activity were used to study. Results: (1)The step-through test showed that the number of mistakes(M) in magnetic field pole N + hypoxia group and magnetic field pole S+ hypoxia group were 2.42±1.08 and 2.50±1.17 respectively, the escape latencies(EL) were (71.08±19.55)s and (53.00±19.75)s respectively,significantly different from those of hypoxia group〔M: 3.58±1.08,EL: (32.50±11.60)s〕,indicating less M and longer EL value(P<0.01,P<0.05), especially in magnetic field pole N + hypoxia group.(2) The number of independent activities in hypoxia group(104±22.07)was significantly less than those in blank control group, magnetic field pole N+hypoxia group and magnetic field pole S+ hypoxia group(185±41.15,187±37.16 and 182±29.13 respectively,P<0.01)while those in both magnetic field groups restored to normal control level. Conclusion: Prophylactic treatment with non-uniform-permanent magnetic field, especially with pole N could improve learning and memory impairment induced by hypobaric hypoxia.

关 键 词：低压缺氧 学习记忆 非均匀恒磁场 

分 类 号：R312[医药卫生—基础医学] R454.1