3-烃基-4-氨基-5-巯基-1,2,4-三唑类化合物的核磁共振碳谱与氢谱研究  

A study on the ^(13)C NMR and ~1H NMR Spectra of 3-Alkyl-4-amino-5-mercapto-1,2,4-triazoles

作　　者：张力学[1] 叶筱琴[2] 张安将[1] 陈小华[1] 周光强[1] 徐志雄[1] 张自义[3] 

机构地区：[1]温州师范学院化学系,浙江温州325003 [2]温州医学院化学教研室,浙江温州325027 [3]兰州大学化学系,甘肃兰州730000

出　　处：《温州医学院学报》2002年第3期137-139,共3页Journal of Wenzhou Medical College

基　　金：国家自然科学基金资助项目 (批准号 :2 980 2 0 0 4) ;教育部高校骨干教师资助计划基金;浙江省教育厅科研资助项目

摘　　要：目的 :研究有机合成重要中间体 3 烃基 4 氨基 5 巯基 1,2 ,4三唑的核磁共振谱的性质。方法 :合成了 3 位分别有苯基、吡啶基、呋喃基、萘甲基、葡萄糖残基等的 4 氨基 5 巯基 1,2 ,4 三唑 ,用BrukerA vance 30 0核磁共振仪测定了碳谱与氢谱 ,并对碳谱谱峰一一进行归属。结果 :这类化合物三唑环两个碳原子化学位移δ值分别为 145 15 2 ,16 5 16 8,氨基氢化学位移为 5 .5 5 .8,巯基氢化学位移为 13.5 14.2。三唑与旁边的芳环、芳杂环之间的亚甲基碳化学位移为 30左右 ,氢化学位移为 4.1到 4.5。结论 :三唑环两个碳化学位移之差与 3 位取代基有关 ,在所测实例中以连呋喃基为最大 ,连苯基、吡啶基、芳甲基依次降低 ,连葡萄糖残基时差值最小。Objective:To investigate the NMR spectral properties of 3-alkyl-4-amino-5-mercapto-1,2,4-triazoles, several of the title compounds have been synthesized.Methods: There is a phenyl, pyridyl, furyl, naphthylmethyl, glucose residue group at the 3-position respectively. The 13 C NMR and 1 H NMR spectra of the title compounds have been determined by Bruker Avance-300 instruments. Furthermore, all the 13 C NMR absorption peaks were attributed one by one.Results:It showed that the chemical shifts δ values of the two triazole carbons were 145-152 and 165-168 respectively. At the same time , the proton chemical shifts δ values of NH 2 and SH were 5.5-5.8, and 13.5-14.2 respectively. The methylene groups between the triazole ring and aryl ring or heterocyclic ring showed carbon δ values at 30 or so,and the corresponding proton chemical shift values were 4.1-4.5.Conclusion:3-substituent is related to the difference of chemical shifts δ values of the two carbons in the triazoles,which are reduced by degree in the order of furyl, phenyl, pyridyl, arylmethyl, and glucose residue. [FK(WB80011?6]

关 键 词：3-烃基-4-氨基-5-巯基-1 2 4三唑 NMR谱 谱峰归属 规律 

分 类 号：O626.27[理学—有机化学]