青壮年猝死综合征心肌结构蛋白免疫组化研究  

Immunohistochemical Study of Actin In Myocardium of Sudden Manhood Death Syndrome

作　　者：于家华[1] 姜英[1] 刘盾[1] 李瑞琴[1] 盛树青[1] 

机构地区：[1]扬州大学医学院,225001

出　　处：《长治医学院学报》2002年第2期81-83,共3页Journal of Changzhi Medical College

基　　金：江苏省教委计划课题;扬州大学青年科研基金 (Y 970 0 11)

摘　　要：目的 :探讨心肌细胞内结构蛋白在青壮年猝死综合征死因诊断方面的价值。方法 :应用免疫组化LSAB法对 1 6例青壮年猝死综合征病例进行心肌细胞内肌动蛋白及肌红蛋白的研究 ,并以 1 3例冠心病猝死病例和 1 5例非心性死亡病例分别作阴性和阳性对照。结果 :1 6例青壮年猝死综合征病例中 ,肌动蛋白染色 ,1 3例明显缺失 ,2例轻度缺失 ,1例无缺失 ;肌红蛋白染色 ,1 2例明显缺失 ,3例轻度缺失 ,1例无缺失。 1 5例冠心病猝死阴性对照组 ,心肌细胞内肌动蛋白和肌红蛋白均明显缺失。 1 5例非心性死亡阳性对照组 ,心肌细胞内肌动蛋白及肌红蛋白均无缺失。结论心肌细胞内结构蛋白的免疫组化检测可作为青壮年猝死综合征死因诊断的指标。Objective:To study the value of diagnosis for the cause of death of sudden manhood death syndrome(SMDS).Method:Actin in myocardium from 16 cases of SMDS and control groups was detected by Immunohistochemical technique(LSAB method).Negative control group included 15 cases of sudden coronary death(SCD) and positive control group included 15 cases of non-cardiac death.Result:There were marked deletion of actin in myocardium from 13 case of SMDS,slight deletion from 2 case,and no deletion from 1 case of SMDS.The marked deletion of actin was observed in negative control group,and there was no deletion of actin in positive control group.Conclusion:Immunohistochemical detection of actin of in myocardium may be an index approach for diagnoseing the causes of death of SMDS.

关 键 词：青壮年 猝死综合征 肌动蛋白 肌红蛋白 免疫组化 LSAB法 

分 类 号：R541.78[医药卫生—心血管疾病]