抗病毒1号中药有效部位体外对流感病毒A_3的抑制作用  

The anti-influenza A_3 effect of an active compound from a Chinese medicinal herb No.1

作　　者：常曼丽[1] 李洪源[1] 杨迎春[2] 佟奎明[1] 周昆[1] 

机构地区：[1]哈尔滨医科大学流行病学教研室,黑龙江哈尔滨150001 [2]哈尔滨医科大学网络信息中心,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2002年第3期212-214,共3页Journal of Harbin Medical University

摘　　要：目的　探讨开发安全有效的抗流感病毒新药。方法　采用细胞培养技术 ,以病毒唑为阳性对照药 ,观察抗病毒 1号中药有效部位 (AD1)在MDCK细胞中对流感病毒A3的抑制作用。结果　AD1半数中毒浓度 (TC50 )为2 6 .95mg ml;抗流感病毒A3的半数有效浓度 (EC50 )为 2 .4mg ml;治疗指数 (TI)为 11.2 3;染毒后 0～ 8h分别给药均有抗病毒活性 ,且对流感病毒A3的抑制作用存在明显的量效反应关系。结论　抗病毒 1号中药有效部位在MDCK细胞中对流感病毒A3有明显抑制作用。Objective To develop new safe and effective anti influenza agents.Methods The anti viral effect of an active compound from a Chinese medicinal herb No.1(AD1) was observed by means of the technique of MDCK cell culture using Ribavirin as a positive control. Results In MDCK culture, AD1 was found to be a inhibitor of influenza A 3 virus in a concentration-dependent manner, with TC 50 of 26.95mg/ml, EC 50 of 2.4 mg/ml and TI of 11.23; AD1 had anti viral effect while it was added 0～8h post infection.Conclusion AD1 has significant anti influenza A 3 effect.

关 键 词：抗病毒1号中药 流感病毒A3 抗病毒作用 有效部位 流感 中药治疗 

分 类 号：R285.5[医药卫生—中药学] R259.117[医药卫生—中医学]