IGF-Ⅰ对庆大霉素诱发大鼠肾损伤保护作用的实验研究  

Experimental investigation of IGF-Ⅰ protection on rat kidney injury caused by GM

作　　者：邸波[1] 周颖 王捷[1] 吴红赤[1] 解汝娟[1] 

机构地区：[1]哈尔滨医科大学第一临床医学院肾内科 [2]哈尔滨市第九医院,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2002年第3期219-220,226,共3页Journal of Harbin Medical University

摘　　要：目的　探讨胰岛素样生长因子 Ⅰ (IGF Ⅰ )对庆大霉素 (GM)致大鼠肾脏损伤时肾功能变化以及血丙二醛(MDA)、古胱甘肽过氧化物酶 (GSH Px)变化的影响。方法　采用GM腹腔注射制备肾损伤动物模型 ,以IGF Ⅰ作为保护因素 ,分别检测血尿素氮、肌酐水平以及血MDA含量、GSH Px活性。结果　IGF Ⅰ组大鼠肾功能及形态学损伤与GM组相比明显减轻 ,全血GSH Px活性增高。结论　IGF Ⅰ能促进GM肾损伤肾小管上皮细胞再生修复 ,减轻肾脏损伤 ,改善肾功能 ,对GM肾脏损伤具有一定的保护作用。Objective To investigate the effect of insulin like growth factor Ⅰ(IGF Ⅰ) on renal function and on changes of MDA?GSH Px in rat model of kidney injury caused by garamycin (GM).Methods Based on kidney injury model caused by GM,the concentrations of BUN?SCr?MDA and GSH Px were detected. Results In the IGF Ⅰ protection group, the renal function and morphology significantly relieved and activity of GSH Px increased compared with non protection group. Conclusion IGF Ⅰ can help to regenerate and to plerosis injury of renal tubule epithelial cells caused by GM;also can relieve injury of kidney and ameliorate renal function. IGF Ⅰ has protective effect on injury of kidney caused by GM.

关 键 词：胰岛素样生长因子-Ⅰ 庆大霉素 肾损伤 保护作用 动物实验 肾功能 丙二醛 过氧化物酶 

分 类 号：R692[医药卫生—泌尿科学] R965[医药卫生—外科学]