高血压病合并心力衰竭时使用硝苯地平、氨氯地平治疗的对比观察  

Nifedipine vs amlodipine in treating essential hypertension with chronic heart failure

作　　者：宁波[1] 王文清[1] 王新宴[1] 任秀琴 郭华朝[1] 

机构地区：[1]空军总医院老年病科,北京100036

出　　处：《空军总医院学报》2002年第2期76-77,共2页Journal of General Hospital of Air Force,PLA

摘　　要：目的　观察高血压病合并心衰时使用硝苯地平、氨氯地平治疗时对心脏影响。　方法　 4 7例高血压病合并心衰患者 ,分为硝苯地平治疗组 (30 mg/d,n=2 5 )及氨氯地平 (5 m g/d,n=2 2 )治疗组。观测 2 4 h平均血压、平均心率 ,脉压 ,左室射血分数 (L VEF)、舒张早期减速度 (Dct)、左室等容舒张时间 (IVRT)。　结果　血压、心率、L VEF两组差异不显著 (P>0 .0 5 ) ;平均脉压、IVRT硝苯地平组大于氨氯地平组 (P<0 .0 1) ;硝苯地平组 Dct小于氨氯地平组 (P<0 .0 1)。　结论　高血压合并心衰时使用硝苯地平增大脉压差 ,并影响心脏的舒张功能。Objective To study the effect of nifedipine and amlodipine in patients with essential hypertension(EN) and chronic heart failure(CHF). Methods 47 patients with EN and CHF were randomized to take nifedipine(30 mg per day, n=25) and to take amlodipine(5 mg per day, n=22). Blood pressure, heart rate, pulse pressure, left ventricular ejection fraction (LVEF), deceleration time of E velocity (Dct), LV isovolumic relaxation time (IVRT) were measured. Results There were no significant difference in blood pressure, heart rate, LVEF, between patients with nifedipine and amlodipine treatment(P>0.05). These patients with nifedipine treatment obviously increased pulse pressure and IVRT(P< 0.01 ), and decreased DcT(P<0.01) versus amlodipine treatment. Conclusion The treatment of nifedipine in patients with EN and CHF may increased pulse pressure and damaged LV diastolic function.

关 键 词：硝苯地平 氨氯地平 高血压 充血性心力衰竭 药物治疗 对比分析 

分 类 号：R544.1[医药卫生—心血管疾病] R541.61[医药卫生—内科学]