抗生素C3221-A的分离及结构鉴定  

Isolation and dentification of Antibiotic C3221 - A

作　　者：鲁敏[1] 陈汝贤[1] 

机构地区：[1]中国医学科学院/中国协和医科大学医药生物技术研究所,北京100050

出　　处：《医学研究通讯》2002年第7期37-39,共3页Bulletin of Medical Research

摘　　要：对嗜热放线菌X3221的发酵液进行溶剂萃取、Sephadex LH-20柱分离、中压控纯化,得到一具有抗菌和抗肿瘤活性的抗生素C3221-A。通过理化性质比较和结构单定确定其为Thermorubin A。An Antibiotic C3221 - A which has the antibacterial activity and antitumor activity was extracted with solvent, isolated by sephadex LH - 20 and purified by YMC - ODS column form fennentation broth of Thermoactinomyces sp.C3221.By means of the determination of UV、IR、MS、1H- NMR spectra, C3221 - A was identical with Thermorubin A.

关 键 词：抗生素C3221-A 结构鉴定 ThermorubinA 嗜热放线菌 制备方法 

分 类 号：R978.1[医药卫生—药品]