β-环糊精衍生物对黄酮类药物的增溶作用  

Enhanced Solubility of Flavonoids by Inclusion with β-Cyclodextrin and Its Derivatives

作　　者：王茹林[1] 杨郁[1] 双少敏[1] 潘景浩[1] 

机构地区：[1]山西大学化学化工学院

出　　处：《应用化学》2002年第7期702-704,共3页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金 (2 0 172 0 3 5 );国家教育部优秀青年教师资助计划项目

摘　　要：The inclusion interactions between flavonoids and β cyclodextrin( β CD) and its derivatives have been studied by a phase solubility method. The phase solubility graphs showed that the 1∶1 inclusion compounds were formed beween β CD and rutin, qucertin and morin respectively. The compounds appeared to be a type of A L inclusion. β CD derivatives have stronger binding capacity than β CD. The enhanced solubility of compounds decreased in the order methyl β CD>hydroxypropyl β CD> β CD. The highest solubility was obtained in methyl β CD inclusion complex with qucertin in level of 50 times than that in water.The inclusion interactions between flavonoids and β cyclodextrin( β CD) and its derivatives have been studied by a phase solubility method. The phase solubility graphs showed that the 1∶1 inclusion compounds were formed beween β CD and rutin, qucertin and morin respectively. The compounds appeared to be a type of A L inclusion. β CD derivatives have stronger binding capacity than β CD. The enhanced solubility of compounds decreased in the order methyl β CD>hydroxypropyl β CD> β CD. The highest solubility was obtained in methyl β CD inclusion complex with qucertin in level of 50 times than that in water.

关 键 词：相溶解度 Β-环糊精衍生物 黄酮类药物 增溶作用 包含作用 药物载体 

分 类 号：R944.9[医药卫生—药剂学]