金属离子对蛋白质的折叠、识别、自组装及功能的影响  

The Influences of Metal Ions on Protein Folding,Recognition, Self-Assembly and Biological Functions

作　　者：蒋明[1] 沈涛[1] 徐辉碧[1] 刘长林[1] 

机构地区：[1]华中科技大学化学系,武汉430074

出　　处：《化学进展》2002年第4期263-272,共10页Progress in Chemistry

基　　金：国家自然科学基金资助项目 (2 98710 11)

摘　　要：金属离子不仅影响金属蛋白的空间结构 ,还与生物大分子的识别、自组装等性质和生物功能密切相关。在很多蛋白质中 ,金属离子及其配合物可以诱导周围的肽段折叠成正确的结构 ,我们将其称为金属结合部位作为模板诱导的结构基序 ( template- mediated structural motif,TMSM)。深入研究金属离子在蛋白质 -核酸自组装体系中和生物大分子交联及聚集体中的作用 。Metal ions and their complexes can exert influences on not only three-dimensional structures of proteins, but also biomacromolecular recognition, self-assembly and functions. The metal ions or their complexes can act as templates that mediate the peptide chains around to fold them into correct structures, which is designated as template-mediated structural motif (TMSM). It is of great significance for the bioinorganic chemists to understand the roles of metal ions in the self-assembly of protein-DNA/RNA and biomacromolcular cross-linking and aggregation states.

关 键 词：蛋白质 功能 金属离子 TMSM 折叠 识别 自组装 核酸 生物大分子 生物无机化学 

分 类 号：Q51[生物学—生物化学] Q58