镇咳宁糖浆质量标准的研究  

Study on Quality Level of Zhenkening Syrup

作　　者：邸多隆[1] 刘晔玮[2] 孙芸 刘霞[1] 蒋生祥[1] 

机构地区：[1]中国科学院兰州化学物理研究所,甘肃兰州730000 [2]河西学院化学系,甘肃张掖734000 [3]甘肃省张掖地区药检所,甘肃张掖734000

出　　处：《分析测试技术与仪器》2002年第2期92-94,共3页Analysis and Testing Technology and Instruments

摘　　要：用RP -HPLC测定了镇咳宁糖浆中盐酸麻黄碱的含量 .色谱条件 :ShimadzuODS柱 (5 μm ,id 4 .6× 2 5 0mm) ,流动相为乙腈 /醋酸铵缓冲液 (pH 4 .5 ) (2 5 / 75 ,v/v) ,流速 1mL/min ,检测波长 2 5 7nm ,平均回收率 98.96 % ,RSD0 .35 % (n =9) ,最小检测限 0 .4 μg .A RP HPLC method was developed for Determination of Ephedrine Hydrochloride in Zhenkening Syrup. Chromatographic column,Shimadzu ODS (5 μm ,id 4.6×250 mm). Mobile phase, acetonitrile/ ammonium acetute buffer solution (25/75, v/v ). Detection wavelength, 257 nm. The linear correlation was good in the range of 0.4～3.0 μg of Ephedrine Hydrochloride in Zhenkening Syrup (r=0.999 7). The average recovery was 98.96 %(n=9) and RSD was 0.35 %. The method is simple, rapid and accurate.

关 键 词：质量标准 盐酸麻黄碱 镇咳宁糖浆 HPLC 中药复方制剂 分析 高效液相色谱 

分 类 号：TQ461[化学工程—制药化工] R284.1[医药卫生—中药学]