人类细小病毒B19感染与新生儿病理性黄疸关系的临床研究  

Association of human parvovirus B19 infection with pathologic jaundice in newborn infants

作　　者：余建莉[1] 蔡定邦[1] 陈享[1] 梁星群[1] 

机构地区：[1]广东省肇庆市第一人民医院,526021

出　　处：《中国实用儿科杂志》2002年第7期407-408,共2页Chinese Journal of Practical Pediatrics

摘　　要：目的　了解新生儿病理性黄疸人类细小病毒B19感染情况及临床特征。方法　采用巢式聚合酶链反应(Nested PCR)技术对 130例病理性黄疸新生儿进行血液B19DNA检测 ,以同期 80例健康新生儿的血液作对照组。结果　 130例新生儿病理性黄疸的血液B19DNA阳性率为 34 6 % (45 / 130 ) ,对照组为 8 8% (P <0 0 1)。在 4 5例B19阳性的新生儿病理性黄疸中有 2 5例为新生儿溶血性疾病 ,6例为头颅血肿 ,其余为感染性疾病 ;且具有贫血、出血、发热、皮疹等临床特点 ,少数病例出现一过性再障危象与多脏器功能损害。结论　①细小病毒B19感染是新生儿病理性黄疸较重要的原因。②B19与新生儿病理性黄疸密切相关 ,且对病情与临床表现有一定的影响。Objective To investigate human Parvovirus (HPV) B19 infection and its effect in pathologic jaundice of newborn infants.Methods 130 serum specimens from neonatal pathologic jaundice were tested B19 DNA with nested polymerase chain reaction (PCR) and 80 healthy newborns served as control group.Results B19 DNA positive rate was 34 6% (45/130) in all patients, compared to 8 8% in control group (P<0 001).In 45 cases B19 positive neonatal patients,there was 25 newborn hemolytic diseases,6 cephalhematoma and infectious diseases,which characterized by anemia,hemorrhage,fever,rash,even temporary aplastic crisis and multiple organ dysfunction syndrome in a few case.Conclusin ①HPV B19 infection is the important reason for pathologic jaundice in newborn infants.②B19 is closely correlated with neonatal pathologic jaundice and has some effect on its clinical characteristics.

关 键 词：细小病毒B19感染 新生儿病理性黄疸 巢式聚合酶链反应 病因 

分 类 号：R722.17[医药卫生—儿科]