双氯酚酸钠眼膏在家兔眼部的相对生物利用度  

The Relative Bioavailability of Diclofenac Sodium Eye-ointment in Rabbit Eye

作　　者：孙考祥[1] 阎红[2] 郑秋艳[1] 彭绍民[1] 孙大为[1] 王绍伟[1] 

机构地区：[1]哈尔滨医科大学附属第二医院,哈尔滨市150086 [2]哈尔滨二四二医院,哈尔滨市150066

出　　处：《中国药房》2002年第7期392-393,共2页China Pharmacy

基　　金：黑龙江省科委资助项目 (G97L1919)

摘　　要：目的 :测定双氯酚酸钠眼膏在家兔眼部的相对生物利用度 ,评价双氯酚酸钠眼膏在眼部的经 -时过程 ,为临床应用提供参考。方法 :48只家兔随机分为两组 ,其眼部分别应用0 1 %双氯酚酸钠眼膏和滴眼液 ,于不同时间抽取房水、分离虹膜 ,采用高效液相色谱法测定眼组织中的药物浓度。结果 :眼膏组较滴眼液组具有较高的组织药物浓度 ,较长的消除半衰期 ,达峰时间与滴眼液相同 ;眼膏在房水和虹膜的相对生物利用度分别为183 33 %和205 68 %。结论 :双氯酚酸钠眼膏吸收程度较滴眼液高并具有缓释作用 ,临床上可减少用药次数 。OBJECTIVE:To determine the retative bioavailability of Diclofenac sodium eye-ointment in rabbit eyes and to evaluate its pharmacokinetics following topical application METHODS:48 rabbits were divided into two groups 0 1% Diclofenac sodium eye-ointment and Diclofenac sodium eyedrops were applied topically to rabbit eyes and aqueous humor and iridic tissue were collected at given times The concentration of Diclofenac sodium in tissue were measured by HPLC RESULTS:Diclofenac sodium eye-ointment group had higher concentration and longer half-time than Diclofenac sodium eyedrops group,however,the peak time were the same in two groups The relative bioavailabilities of Diclofenac sodium ointment in aqueous humor and iridic tissue were 183 33% and 205 68% respectively,compared with those of Diclofenac sodium eyedrops CONCLUSION:Diclofenac sodium eye-ointment can be absorbed well and released slowly,which can reduce the frequency of application of drug It is especially suitable for operation patient or application at night

关 键 词：双氯酚酸钠 相对生物利用度 眼膏 DCF 药代动力学 

分 类 号：R965[医药卫生—药理学]