锌缺乏对胎鼠中枢神经递质水平的影响  

Effect of zinc deficiency on the level of central neurotransmitters in brain of rat fetuses

作　　者：赵长峰[1] 谢军[1] 赵秀兰[1] 王菊生[2] 毕文婕[3] 赵丽[1] 姜会敏[1] 

机构地区：[1]山东大学公共卫生学院 [2]济南市中心医院 [3]济南铁路中心卫生防疫站

出　　处：《山东大学学报（医学版）》2002年第3期230-231,234,共3页Journal of Shandong University:Health Sciences

基　　金：山东省自然科学基金资助课题 (Y96C110 43)

摘　　要：目的 :研究缺锌对胎鼠发育及其脑组织内中枢神经递质去甲肾上腺素 (NE)、多巴胺 (DA)、5 羟色胺 (5 HT)含量的影响。方法 :将Wistar孕鼠随机分为缺锌组、对饲组和对照组 ,分别给予缺锌和正常锌饲料饲养 ,于妊娠第 2 1天取其胎鼠称重 ,测定胎鼠和胎盘中微量元素及脑内中枢神经递质含量。结果 :缺锌组胎鼠体重显著低于对照组和对饲组 (P <0 .0 1) ;各组胎鼠的脑重量无明显差异 ;缺锌组胎鼠脑组织中NE和DA含量显著高于对照组和对饲组 (P <0 .0 1) ;缺锌组胎鼠、胎盘中锌含量显著低于对照组和对饲组 ,而铁含量则显著升高 (P <0 .0 1) ;胎鼠体内铜含量也处于较高水平。结论 :锌缺乏能对胎鼠脑内中枢神经递质含量产生影响 。Objective:To study the effect of zinc(Zn) deficiency on the growth and concentrations of central neurotransmitters, i.e. norepinephrine (NE), dopamine (DA),5-hydroxytryptamine (5-HT), in the brain of rat fetuses. Methods: Pregnant Wistar rats were randomly divided into three groups: Zn deficiency (D), Pair-fed (P) and control group (C). The rats of D group were fed with a Zn deficient diet and others were fed with a similar diet supplemented with Zn. On the 21st day of gestation, laparotomy was performed to remove and weigh the placentas, fetuses and their brains , and the concentrations of trace elements in placentas and fetuses and those of central neurotransmitters in the brain were determined. Results: Body weight of fetuses of D group was significantly lower than that of other groups (P<0.01). There was no difference in brain weight of fetuses among three groups. The concentrations of NE and DA in the brain were significantly increased in fetuses of C and P groups (P<0.01). The concentrations of Zn in fetuses and placentas of D group were significantly lower than those of other groups (P<0.01),while, Fe concentration increased remarkably. The copper concentration in fetuses of D group was also high. Conclusion:Zn deficiency can affect the concentrations of central neurotransmitters in the brain of rat fetus, which may be induced by the changes of metabolism of trace elements.

关 键 词：锌缺乏 胎鼠 中枢神经递质 神经调节剂 

分 类 号：R591.1[医药卫生—内科学]