高血压病血压昼夜节律与血浆血管紧张素Ⅱ水平的研究  

Relationship between circadian rhythm of blood pressure and plasma angiotensin Ⅱ levels in patients with hypertension

作　　者：石蓓[1] 孙全林[1] 曾远杨[1] 徐昆[1] 何国平[1] 

机构地区：[1]遵义医学院附属医院心内科,563003

出　　处：《贵州医药》2002年第7期599-600,共2页Guizhou Medical Journal

基　　金：遵义市科委资助课题

摘　　要：目的探讨高血压患者血压昼夜节律紊乱与血浆血管紧张素Ⅱ (AngⅡ )水平的关系。方法 6 2例高血压病患者行 2 4小时动态血压测定 ,根据夜间平均动脉压下降 10 %以上或以下的标准将患者分为杓型组 (34例 )与非杓型组 (2 8例 ) ,以 2 0例血压正常者为对照组 ,测定血浆AngⅡ浓度。结果非杓型高血压组血浆AngⅡ水平显著高于杓型组 ,且血浆AngⅡ水平与动态血压值正相关。结论肾素—血管紧张素系统是调节血压节律的重要系统 ,AngⅡ可能参与夜间血压升高 ,提示高血压患者的血压昼夜节律紊乱与AngⅡ水平有关。Objective To investigate the relationship between plasma angiotensin Ⅱ levels and loss of diurnal rhythm of blood pressure in hypertensive patients.Method According to ambulatory blood pressure,62 patients with essential hypertension were divided into dipper group(n=34) and nondipper group(n=28) 20 normotensives were selected as controls.Radio-immunoassy was used for the determination of plasma angiotensin Ⅱ levels.Results Plasma angiotensin Ⅱ levels were normal in the dipper group,but were higher significantly in the non-dipper group.In the non-dipper group,plasma angiotensin Ⅱ levels significantly correlated with 24-hour ambutatory blood pressure.Conclusions The Renin-angiotensin system may be involved in both the pathomechanism of hypertension and the diurnal rhythm of blood pressure.Elevation of plasma angiotensin Ⅱ level is related with loss of diurnal rhythm of blood pressure in essential hypertension with complication.

关 键 词：高血压 血压 昼夜节律 血管紧张素Ⅱ 病理 

分 类 号：R544.102[医药卫生—心血管疾病]