HGV单独及重叠HBV、HCV感染64例临床分析  

Clinical analysis of stigma of HGV single infection & superinfection with HBV & HCV

作　　者：吴引伟[1] 刘新钰[1] 姚启燕[1] 

机构地区：[1]东南大学医学院附属南京第二医院肝病研究室,江苏南京210003

出　　处：《东南大学学报（医学版）》2002年第2期181-183,共3页Journal of Southeast University(Medical Science Edition)

摘　　要：目的 :了解庚型肝炎病毒 (HGV)单独及重叠乙型肝炎病毒 (HBV)、丙型肝炎病毒 (HCV)感染的临床特征 ,探讨其致病性。方法 :用套式聚合酶链反应 (PCR)检测患者血清中HGVRNA ,用ELISA和 (或 )PCR法对其他肝炎病毒标志物进行血清学检测。结果 :从临床分型来看 ,HGV单独感染者以急性肝炎 (AH)多见 ,占 47.1% ;重叠HBV感染者以肝硬化 (LC)多见 ,占 5 1.3 % ;重叠HCV感染者以慢性肝炎 (CH)多见 ,占 75 %。各组间比较均有显著性差异 (P <0 .0 5 )。从肝功能恢复情况来看 ,各组间均无显著性差异 (P >0 .0 5 )。结论 :HGV单独感染多表现为AH ,重叠HBV、HCV感染时对病情影响不明显 。Objective To study the clinic stigma of HGV single infection and superinfection with HBV and HCV,and analyze its pathogenesis.Methods HGV RNA in serum samples were detected by nested polymerase chain reaction (PCR),the markers of other hepatitis virus in serum were detected by ELISA and/or PCR.Results Clinical classification manifestation,47.1% of HGV single infection patients were acute hepatitis (AH) more than others. 51.3 % and 75% of superinfection with HBV and HCV patients were liver cirrhosis(LC) and chronic hepatitis(CH).There were significantly differences among HGV single infection and HGV superinfected HBV and HCV( P <0.05).There were no differences among the HGV single infection and superinfection with HBV and HCV in the instauration circumstance of ALT ( P >0.05).Conclusion Most of HGV single infection patients display as acute hepatitis,the state of illness has no obvious changes when HGV superinfected with HBV and HCV.The results suggest that HGV might have pathogenesis.

关 键 词：HGV HBV HCV 庚型肝炎病毒 乙型肝炎病毒 病毒性肝炎 重叠感染 聚合酶链反应 诊断 

分 类 号：R512.6[医药卫生—内科学]