232对自然流产夫妇细胞遗传学及免疫学分析  

Analysis of Cytogenetics and Immunology in 232 Couples with Spontaneous Abortion

作　　者：金洁[1] 程建军[1] 

机构地区：[1]江苏大学医学院生物学教研室,江苏镇江212001

出　　处：《江苏大学学报（医学版）》2002年第3期244-245,共2页Journal of Jiangsu University：Medicine Edition

摘　　要：目的 :探讨遗传学及免疫因素与自然流产的相关性。方法 :对自然流产组进行染色体检测 ,采用酶联免疫吸附法(ELISA)对自然流产组和对照组分别进行抗心磷脂抗体 (AcA)和子宫内膜抗体 (EMAb)的检测。结果 :2 3 2对自然流产夫妇中 ,核型异常发生率为 4.8% ,EMAb阳性率为 3 9% ,AcA阳性率为 3 0 % ,且 2次以上流产妇女比 1次流产妇女AcA阳性率高 (P <0 .0 5 )。结论 :在自然流产夫妇中进行细胞遗传学和免疫学检查对于流产的病因。Objective:To investigate the relationship between the spontaneous abortion and factors of cytogenetics and immunology. Methods:AcA and EMAb were investigated with ELISA and analysis of chromosome in couples with spontaneous abortion was done. Results :The frequency of abnormal karyotypes in 232 couples with spontaneous abortion was 4.8%.The positive rate of EMAb was 39%, The positive rate of AcA was 30%, and the positive rate of AcA in women with abortion of more than twice was higher than that in women with abortion only once( P <0.05). Conclusions:The results show it was important to analye cytogenetics and immunology in couples with spontaneous abortion.

关 键 词：自然流产 染色体 子宫内膜抗体 抗心磷脂抗体 

分 类 号：R714.2[医药卫生—妇产科学]