左旋四氢巴马汀对肠道平滑肌的作用  

The effect of 1-tetrahydropalmatine (1-THP) on intestinal smooth muscle

作　　者：王贵林[1] 王文英[1] 

机构地区：[1]湖北省卫生职工医学院药理教研室,荆州434000

出　　处：《中药药理与临床》2002年第3期9-10,共2页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：左旋四氢巴马汀 (1 THP) 2 0 3 2 0mg/kg灌胃给药能剂量依赖性减慢小鼠小肠推进运动。在离体器官实验中 ,1 THP能抑制家兔十二指肠和豚鼠回肠的自发活动 ,非竞争性拮抗His和Ach引起的豚鼠回肠收缩 ,并能松弛高钾去极化和氯化钡引起的豚鼠结肠带收缩。1 THP given orally in doses of 20～320mg/kg could dose dependently slow the propelling movement of intestine in mice. It suppressed the spontaneous movement of rabbit duodenum and guinea pig ileum in vitro, antagonized nonpetitively contraction of guinea pig ileum induced by cumulative concentration of His and Ach. It also resulted in relaxing effects on contraction of guinea pig taenia colon.

关 键 词：左旋四氢巴马汀 组胺 乙酰胆碱 肠平滑肌 药理 

分 类 号：R285.5[医药卫生—中药学]