植入用缓释氟尿嘧啶的人体内血药浓度经时方程初探  

Study on plasma concentration-time equation of 5-fluorouracil sustained-release subcutaneous implant in human volunteer

作　　者：储成顶 张海燕[1] 许健健[2] 王彭三[2] 吴荣莲 

机构地区：[1]安徽中人科技有限责任公司 [2]合肥工业大学控释药物研究室,合肥230009

出　　处：《中国新药杂志》2002年第7期540-543,共4页Chinese Journal of New Drugs

基　　金：中华人民共和国科学技术部基础研究快速反应支持项目 (国科基字 [2 0 0 1] 5 1号 )

摘　　要：目的 :探讨并建立植入用缓释氟尿嘧啶的人体内血浆浓度经时模型。方法 :分析体内过程 ,建立微分方程 ,求解与证明。结果 :经 19例试验者数据拟合 ,其人体内血药浓度经时模型为 :单室开放式模型 ,血药浓度方程C =A1 e-Ket+A2 e-Kat+A3e-Krt。结论 :此方程为植入剂药代动力学参数的计算提供理论参数。Objective:To discuss and set up plasma concentration time equation of 5 fluorouracil sustained release subcutaneous implant in human.Methods:The in vivo process of the drug was analyzed,and the differential equation was set up.The solution was found.Results:Afte the data of 19 patients were analyzed,the plasma concentration time curve was fitted to one compartment open model.The plasma concentration time equation was C =A 1 e -Ke t +A 2 e -Ka t +A 3 e -Kr t .Conclusion:The plasma concentration time equation may provide the theoretical reference for the calculation of the pharmacokinetic parameters of subcutaneous implant.

关 键 词：缓释氟尿嘧淀 药代动力学 血浆浓度经时方程 

分 类 号：R979.11[医药卫生—药品]