复方蒿甲醚和组份之一本芴醇两种剂型治疗恶性疟疾临床对比试验  

Clinical comparative trial of co-artemether, and one of its components benflumetol (two formulations) in treating falciparum malaria

作　　者：孙志伟[1] 单承启[1] 李国福[1] 焦岫卿[1] 刘光裕[1] 丁德本[1] 王京燕[1] 

机构地区：[1]军事医学科学院微生物流行病研究所,北京100071

出　　处：《中国临床药理学与治疗学》1999年第1期21-24,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的 观察复方蒿甲醚及其组份之一本芴醇两种剂型治疗恶性疟疾的疗效和安全性。方法采用双盲（复方蒿甲醚组和本芴醇片剂组），随机对比的方法。病人入院后实行２８天封闭观察。结果 收治１５０例病人，其中复方蒿甲醚组（Ａ）５１例，本芴醇片剂组（Ｂ）５０例，本芴醇胶丸组（Ｃ）４９例；Ａ、Ｂ、Ｃ三组的平均退热时间分别为１７．１±８．６、３４．０±２３．２、２９．４±２４．９小时；平均原虫转阴时间分别为２９．７ ± ８．９、５１．６±１４ ．１、５４．７±１７．４小时；Ａ、Ｂ、Ｃ三组的治愈率分别为９８．２％、９２．０％、９５．８％。三组病人在观察期间均无明显不良反应发生，各项化验检查未见明显异常。结论 复方蒿甲醚和本芴醇两种剂型对恶性疟疾均有良好的治疗作用，但复方蒿甲醚在杀虫速度和控制患者症状方面明显优于本芴醇单药。To observe the effects and safety of co-artemether and one of its components benflumetol (two formulations) for treatment of patients with plasmodium falciparum. Methods 150 patients was recruited, with 51 patients in co-artemether group (A) , 50 patients in benflumetoltablet group(B), 49 patients in benflumetol group (C), The methods of double-blinding,radomization and comparison were applied and all patients were conditioned and observed for 28 days. Results The mean fever clearance time for group A, B and C was 17.1±8.6, 34.0±23.2 and 29.4 ±24.9 hours respectively; mean parasite clearance time was 29. 7±,51.6 ±14.1 and 54. 7 ±17. 4 hours respectively and the cure rate for group A,B and C was 98.22% 92.0% and 95.8% respectively. No significant side-effects was observed and no significant change was found in laboratory test. Conclu sion Co-artemether and one of its components benflumetol (2 formulations) have good curative effect for patients with plasmodium falciparum, but co-artemether is more effective than benflumetol (2 formulations) in velocity for controling symptoms and killing parasites.

关 键 词：复方蒿甲醚 蒿甲醚 本芴醇 恶性疟疾 药物疗法 

分 类 号：R978.61[医药卫生—药品]