乙基西梭霉素在全胃肠外营养病人的药代动力学  

Effects of total parenteral nutrition on pharmacokinetics of netilmicin

作　　者：袁成[1] 贾暖[1] 冯琳[1] 薛作英[1] 梁竹[1] 

机构地区：[1]济南军区总医院药理科,济南250031

出　　处：《中国临床药理学与治疗学》1999年第3期206-208,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的观察在全胃肠外营养(TPN)时病人体内乙基西梭霉素(NTM)的药代动力学。方法用高效液相色谱 -间接光度检测(HPLC_IPD)法测定7例行TPN病人和7例对照病人静滴NTM5mg·kg-1 后血清和尿中药物浓度 ,并计算药代动力学参数。结果NTM在体内处置符合二室开放模型 ,静滴后TPN组NTM血清峰浓度低于对照组 ,但无显著性差异 ,至5h后TPN组浓度开始高于对照组 ,至12h时已明显高于对照组 ;尿中原型药物排出率TPN组较对照组下降 ,但无显著性差异 ;TPN组与对照组血清NTM的t1/2(β)分别为(5.8±1,6)h和(3.5±1.4)h。结论病人给TPN时 ,NTM体内分布和消除变慢。Aim The pharmacokinetics of netilmicin(NTM) in the patients receiving total parenteral nutrition (TPN) was studied. Methods Seven patients with intestines fistula under TPN and seven patients in control group received 5 mg·kg of NTM by iv infusion in 0.5 h.NTM concentrations in serum and urine were determined by a high performance liquid chromatography-indirect photometric determination (HPLC-IPD) method. Pharmacokinetics parameters were computed with the 3p87 program.Results After intravenous administration of NTM 5 mg·kg-1, the NTM chromatography peakconcentration in serum was insignificantly lower in the TPN group than that in the control group (P>0.05),but the NTM level in the TPN group became higher than that in the control group (P>0.05) at 5 th hour and significantly higher at 12 th hour after beginning of administration (P<0.05).The reclamations of original shape NTM in urine were (52±13)% in the TPN group and (63±13)% in the control group.Pharmacokinetics calculations were disposed to two-compartment open-system model with t1/2(β)=(5.8±1.6) h, Vc=(0.47±0.15 )L·kg-1 in TPN and t1/2(β)=(3.5±1.4)h, Vc=(0.28±0.09) L·kg-1 in the control.Conclusio There is a marked drop in the removing rate of NTM from body.

关 键 词：全胃肠外营养 乙基西梭霉素 药代动力学 HPLC-IPD 

分 类 号：R969.1[医药卫生—药理学] R978.1[医药卫生—药学]